Micromixing of a highly viscous biosample with water using orbital shaking and microchannels is considered. Existing methods mix biosamples by only shaking microwells or by specially designed microstirrers which are ineffective or inapplicable for highly viscous materials, let alone small volumes at microliter or nanoliter levels. Our method mixes a viscous biosample with water in microwells us...

The quadrature-based semi-analytical solution for the conditional moment closure (SA-CMC) given in (A. D. Ilgun, A. Passalacqua, and R. O. Fox, “A mixing-sensitive reactions,” Chem. Eng. Sci., 226, 2020) eliminates additional conditioning-space discretization CMC applications by assuming that mixture-fraction PDF is well represented a ?-PDF. A Gaussian quadrature provides abscissae, scalar mean...

The direct simulation Monte Carlo (DSMC) method for population balance modeling is capable of retaining the history of each simulation particle and is thus able to deal with multivariate properties in a simple and straightforward manner. As opposed to conventional DSMC approaches that track equally weighted simulation particles, a differentially weighted Monte Carlo method is extended to simula...

Strong acoustic streaming can be generated inside a microchannel near sharp-edge structures. In this study, three Sharp-Edge Acoustic Streaming (SEAS) micromixers with multiple sharp edge patterns actuated by piezoelectric transducers are investigated. Direct Numerical Simulation (DNS) is used to numerically solve the multi-physics phenomenon involving acoustics, fluid dynamics and mass transfe...

A wide range of microfluidic cell-sorting devices has emerged in recent years, based on both passive and active methods of separation. Curvilinear channel geometries are often used in these systems due to presence of secondary flows, which can provide high throughput and sorting efficiency. Most of these devices are designed on the assumption of two counter rotating Dean vortices present in the...

The joint probability density function (PDF) of turbulent velocity and concentration of a passive scalar in an urban street canyon is computed using a newly developed particle-in-cell Monte Carlo method. Compared to moment closures, the PDF methodology provides the full one-point one-time PDF of the underlying fields containing all higher moments and correlations. The small-scale mixing of the ...