microRNAs represent the best described class of small RNAs (21-23nt) and have been shown to function as post-transcriptional regulators of gene expression. The high relative stability of microRNA in common clinical samples such as serum/plasma, urine and other biofluids, and the ability of micro RNA expression profiles to accurately classify discrete tissue types and specific disease states hav...

Non-alcoholic fatty liver disease is a high-risk factor for the morbidity and mortality of type 2 diabetes mellitus. Thus, we conducted meta-analysis to investigate whether microRNAs associated with non-alcoholic are their potential predict in individuals. We systematic literature search using PubMed, Cochrane library Embase databases. The about circulating microRNA levels nonalcoholic individu...

RATIONALE Viral myocarditis results from an adverse immune response to cardiotropic viruses, which causes irreversible myocyte destruction and heart failure in previously healthy people. The involvement of microRNAs and their usefulness as therapeutic targets in this process are unknown. OBJECTIVE To identify microRNAs involved in viral myocarditis pathogenesis and susceptibility. METHODS A...

Introduction: Malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. Nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. Connexin 43 (Cx43) and micro ribonucleic acid- 21(miR-21) are among molecules that are involved in glioma development and progression. These molecules showed...

Generalized tonic-clonic seizures (GTCS) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Also, among several mechanisms underlying SUDEP there is cardiac dysfunction. So, we aimed to evaluate impact of number on heart function and morphology rats with epilepsy. Rats were randomized into three groups: Sham (without epilepsy), 5 S, 10 S groups, referred as a total or GTC...

Acute myeloid leukemia (AML) is a highly diverse disease characterized by various cytogenetic and molecular abnormalities. MicroRNAs are small noncoding RNAs that show variable expression during myeloid differentiation. MicroRNA expression in marrow blasts in 215 cases of newly diagnosed and (cyto)genetically defined AML was assessed using quantitative reverse-transcription-polymerase chain rea...

To figure out the pathway by which epigallocatechin gallate restrains angiogenesis and glycolysis in colorectal cancer through circular ribonucleic acid (actin gamma 2)/microRNA-370-5p axis. Detection of actin 2 microRNA-370-5p patient tissues cells vascular endothelial growth factor A was conducted. Cell viability proliferation, angiogenesis, glucose lactate were examined. Circular microRNA-37...

Urine accumulates traces of changes that occur in the body and can potentially serve as a better biomarker source. Urinary microRNA is a promising class of non-invasive disease biomarkers. However, long-term frozen human urine samples are not a good source for the extraction of urinary microRNA. In this paper, we demonstrate that urinary microRNA can be concentrated, dried on membranes and stor...