The imbalance between transforming growth factor β and bone morphogenetic protein 7 signaling pathways is a critical step in promoting hepatic stellate cell activation during hepatic fibrogenesis. Gremlin1 may impair the balance. Something remains unclear about the regulatory mechanisms of gremlin1 action on hepatic stellate cell activation and hepatic fibrosis. In the current study, gremlin1 o...

Total flavones of Selaginella uncinata (Desv.) spring has inhibitory effects on cancer progression. The study aims to analyze the total breast cell tumor properties and possible mechanism. MDA-MB-231 cells were treated with or transfected anti-microRNA-negative control anti-microRNA-1269. In addition, microRNA-negative microRNA-1269 mimics-transfected exposed uncinata. Cell proliferation apopto...

BACKGROUND Pancreatic cancer is the fourth leading cause of cancer death in Western countries, with the lowest 1-year survival rate among commonly diagnosed cancers. Reliable biomarkers for pancreatic cancer diagnosis are lacking and are urgently needed to allow for curative surgery. As microRNA (miRNA) recently emerged as candidate biomarkers for this disease, we explored in the present pilot ...

cardiovascular disease has become the main factor of death and birth defects in the world. there are some therapeutic structures and drugs for curative and palliative therapy of the disease, but to the aim of accessing reliable therapy or to postpone onset of disease, especially for individuals with heritable coronary artery disease in their pedigree genetic engineering technologies are making ...

To investigate the effect of pristimerin on gefitinib resistance in lung cancer cells and its regulation microRNA-936. Lung cell HCC827 was cultured vitro, resistant HCC827/gefitinib established were randomly assigned to control group, pristimerin-L pristimerin-M pristimerin-H gefitinib+pristimerin gefitinib+microRNA-negative gefitinib+microRNA-936 gefitinib+pristimerin+anti-microRNA negative g...

To investigate the effect and molecular mechanism of vitexicarpin on biological behavior colorectal cancer cells is objective study. The human epithelial cell line Caco-2 were divided into control group, low, middle high dose groups vitexicarpin, plasmid cloning DNA-circ_0000419 DNA anti-microRNA-224 anti-microRNA-224-negative vitexicarpin+small interfering-circ_0000419 group vitexicarpin+micro...

OBJECTIVE MicroRNAs (miRNAs) are increasingly recognized as fine-tuning regulators of metabolism, and are dysregulated in several disease conditions. With their capacity to rapidly change gene expression, miRNAs are also important regulators of development and cell differentiation. In the current study, we describe an impaired myogenic capacity of muscle stem cells isolated from humans with typ...

Objective(s): The aim of the present study was to investigate the effects of genistein and exercise on the spatial memory and expression of microRNA-132, BDNF, and IGF-1 in the hippocampus of ovariectomized rats. Materials and Methods: Sixty animals were divided into six groups of control, sham, ovariectomy (OVX), ovariectomized with 8 weeks of genistein administration (OVX.G), with 8 weeks of ...