JENNIFER J. YOUNG: Cytoskeleton Micromechanics: A Continuum-Microscopic Approach (Under the direction of Sorin Mitran) Creating accurate, whole-cell scale models of the cytoskeleton is computationally challenging, due to the material’s highly heterogeneous microstructure. Continuumbased models, homogenization methods, and coarse grained models are common modeling approaches. These methods utili...

The need to simulate a number of advanced ITS concepts prior to deployment has also necessitated development of high performance microscopic simulators for estimating dynamic traffic assignment, freeway corridor diversion, as well as evaluating driver information systems (including variable message signs), vehicle guidance systems, real time adaptive traffic control strategies and other traffic...

The a posteriori analysis of the discretization error and the modeling error is studied for a compliance cost functional in the context of the optimization of composite elastic materials and a two-scale linearized elasticity model. A mechanically simple, parametrized microscopic supporting structure is chosen and the parameters describing the structure are determined minimizing the compliance o...

We develop a mesoscopic modeling framework for diffusion in a crowded environment, particularly with applications in the description of living cells. Through homogenization techniques we effectively coarse-grain a detailed microscopic description into a previously developed internal state diffusive framework. In turn, in a certain deterministic limit this framework connects to macroscopic fract...

Agent-based modeling (ABM) is a powerful simulation modeling technique in the last few years. ABM, as an approach to simulating the behavior of a complex system in which agents interact with each other and with their environment using simple local rules, is gaining popularity and widespread use in many areas. Successes of this approach in predicting traffic flow in metropolitan areas, the sprea...

Macroscopic modeling of heat transfer and fluid flow is now routinely used for the prediction of macroscopic defects in castings, while microscopic models are used to investigate the effects of alloy changes on typical microstructures. By combining these two levels of modeling it is possible to simulate the casting process over a wider range of spatial and temporal scales. This paper presents a...

in this study the reproductive organs of adult and apparently healthy female azarbaijan buffaloes werecollected after slaughter from abattoir. through observation of the ovaries, the luteal and follicular phases ofeach buffalo were specified. a total number of 36 oviducts at follicular phase and 36 oviducts at luteal phasewere collected and 3 tissue samples were taken from 3 regions of infundib...

conclusions the occurrence of sam in pauci-autoimmune vasculitis is rarely described, particularly in africa. our case is an illustration of the reality of this association. introduction we reported a case of hemophagocytic syndrome complicating microscopic polyangitis presented by crescentic glomerulonephritis. case presentation a 22-year-old female patient originated from dakar, senegal prese...

The physiological properties of biological soft matter are the product of collective interactions, which span many time and length scales. Recent computational modeling efforts have helped illuminate experiments that characterize the ways in which proteins modulate membrane physics. Linking these models across time and length scales in a multiscale model explains how atomistic information propa...