RESEARCH DESIGN AND METHODS — A longitudinal cohort of 4,623 primary care patients with type 2 diabetes was enrolled in 2000–2002 and followed through 2005–2007. Advanced microvascular complications included blindness, end-stage renal disease, amputations, and renal failure deaths. Advanced macrovascular complications included myocardial infarction, stroke, cardiovascular procedures, and deaths...

IMPORTANCE Glycemic targets in diabetes have been developed to minimize complication risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations have mild fasting hyperglycemia from birth, resulting in an elevated glycated hemoglobin (HbA1c) level that mimics recommended levels for type 1 and type 2 diabetes. OBJECTIVE To assess the association between chronic, mild hyperglycem...

Type 2 diabetes is a chronic disease associated with numerous microvascular and macrovascular complications. It affects millions of persons worldwide, posing an enormous socioeconomic burden. A growing body of evidence shows that comorbidities are greatly reduced when adequate glycemic control is achieved. Unfortunately, despite the variety of therapies currently available, the majority of pati...

Macroand microvascular complications are both main causes of morbidity and mortality in type 1 and type 2 diabetes, but macrovascular complications have an increased incidence even before the onset of type 2 diabetes. While high blood glucose and glucose-induced protein and lipid modifications—the advanced glycation endproducts—can be triggers of both macroand microvascular disease once diabete...

Introduction Diabetes Mellitus is a chronic illness that increases the risk of microvascular complication and results in blindness, kidney failure, and lower extremity amputations, and macrovascular complication of coronary artery disease and stroke. In the State of Hawaii, an estimated eight to ten percent of the population have diabetes mellitus, i.e. about 80,000 to 100,000 individuals, prim...

Macroand microvascular complications are both main causes of morbidity and mortality in type 1 and type 2 diabetes, but macrovascular complications have an increased incidence even before the onset of type 2 diabetes. While high blood glucose and glucose-induced protein and lipid modifications—the advanced glycation endproducts—can be triggers of both macroand microvascular disease once diabete...

Objective. To explore risk factors for macro- and microvascular complications in a nationally representative sample of adults aged 50 years and over with type 2 diabetes in Ireland. Methods. Data from the first wave of The Irish Longitudinal Study on Ageing (TILDA) (2009-2011) was used in cross-sectional analysis. The presence of doctor diagnosis of diabetes, risk factors, and macro- and microv...

OBJECTIVE To assess clinical profiles of patients with type 2 diabetes in the United Arab Emirates (UAE), including patterns, frequencies, and risk factors of microvascular and macrovascular complications. RESEARCH DESIGN AND METHODS Four hundred and ninety patients with type 2 diabetes were enrolled from two major hospitals in Abu Dhabi. The presence of microvascular and macrovascular compli...