TRPA1-related drugs alter sensation, particularly in conditions of inflammation. To further characterize the role these bladder TRPA1 agonist cinnamaldehyde (CMA) and oral true cinnamon spice were examined preclinical models pain. Female adult rats, with without acute zymosan-induced cystitis, anesthetized visceromotor (VMR) cystometric responses to urinary distension (UBD) determined following...

PURPOSE Mammals urinate less frequently during the sleep period than the awake period. This is modulated by a triad of factors, including decreased arousal in the brain, a decreased urine production rate in the kidneys and increased functional bladder capacity during sleep. The circadian clock is genetic transcription-translation feedback machinery. It exists in most organs and cells, termed th...

Since the first reports by Wang and Behar and others the use of epidu-ral and intrathecal opiates for pain relief has become widely accepted. The most common and distressing complication of this mode of anal-gesia is acute urinary retention, which occurs in 3%' to 100%'o2 of patients. We studied the postoperative urinary complications in a group of patients who underwent elective caesarean sect...

In a series of 50 consecutive tumours involving the frontal lobes, seven cases (14%) were found who exhibited the syndrome, first described by Andrew and Nathan in 1964, of frequency of micturition, urgency, and incontinence causing distress to the patient. This suggests that this syndrome may occur rather more commonly than those authors had indicated. In 100 consecutive intracranial tumours, ...

History. ? Atra, aged 22 years, labourer, was brought to the Palumpur Dispensary (Kaugra Valley) oil the 10th June 1887. He staled that he first had the symptoms of stone when he was a boy, and that about eight years ago he was lithotomised, and two large stones were removed. After a few years of ease and comfort the symptoms recurred. Painful and frequent micturition made him miserable. These ...

History of Present Illness.-When admitted to Nakuru, on 2nd April, 1952, he complained of hrematuria accompanied by pain on micturition, of one week's duration. The hrematuria occurred towards the end of micturition and was . accompanied by the passage of a few small clots. The pain was situated in the suprapubic region and radiated to the tip of the penis, being of intermittent and griping cha...

Human micturition is physiologically controlled via a complex and finely tuned network of cortical and subcortical regions, hitherto not fully understood. We report the case of a 42-year-old man with juvenile myoclonic epilepsy (JME) and post-traumatic epilepsy. Ictal enuresis was the only manifestation of the de novo post-traumatic simple autonomic seizures. Source analysis of the ictal epilep...

Control of micturition is a complex physiological and anatomical process which often fails in women. The sequelae of urinary incontinence in women range from inconvenience to social and psychological stigmatization. Surprisingly, many women are tolerant of often quite severe sequelae, despite a range of management techniques that exist to alleviate or cure incontinence. Some of the more success...