BACKGROUND Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance. The aim of this study was to investigate the association of a migraine without aura and Ala379Val polymorphism of lipoprotein-associated phospholipase A2 (Lp-PLA2) gene in the Iranian population. METHODS In this study, 103 migraine patients and 100 healthy controls were enrolled. DNA samples ...

BACKGROUND Numerous studies have explored the effectiveness of complementary and alternative medicine in the treatment of migraine but there is no documented investigation of the effectiveness of yoga therapy for migraine management. OBJECTIVES To investigate the effectiveness of holistic approach of yoga therapy for migraine treatment compared to self-care. DESIGN A randomized controlled t...

Background: Migraine headache without aura is the most common type of migraine especially among pediatric patients. It has always been a great challenge of migraine diagnosis using quantitative electroencephalography measurements through feature classification. It has been proven that different feature extraction and classification methods vary in terms of performance regarding detection and di...

OBJECTIVE To provide updated evidence-based recommendations for the preventive treatment of migraine headache. The clinical question addressed was: What pharmacologic therapies are proven effective for migraine prevention? METHODS The authors analyzed published studies from June 1999 to May 2009 using a structured review process to classify the evidence relative to the efficacy of various med...

Migraine is a primary disorder of the brain with peripheral consequences. The prevalence of migraine is as high as 18% in the general populations. The association between migraine and stroke has been well documented in many case-control and cohort studies. This association has been stronger in patients with migraine with aura compared to migraine without aura and dependent on sex, age, frequenc...

BACKGROUND Open-label trials and small controlled studies report topiramate's efficacy in migraine prevention. OBJECTIVE To assess the efficacy and safety of topiramate as a migraine-preventive therapy. DESIGN A 26-week, randomized, double-blind, placebo-controlled study. SETTING Outpatient treatment at 49 US clinical centers. Patients Patients were aged 12 to 65 years, had a 6-month Inte...

BACKGROUND Studies seeking to establish an association between migraine and anthropometric parameters have thus far been inconclusive. Furthermore, drugs used for migraine prophylaxis may be associated with changes in body weight. OBJECTIVE To investigate the potential association of anthropometric parameters and body fat percentage with attack patterns and use of prophylactic medication in m...

BACKGROUND Cyclic vomiting syndrome (CVS) is an episodic nausea and non-bilious vomiting disorder characterized by recurrent stereotypic symptoms with disease-free intervals. CVS in children is associated with a high prevalence of migraine, and is commonly considered a precursor to migraine. This study aimed to investigate the clinical manifestations of pediatric CVS and its prognosis, and to c...