Dendritic cell chemotaxis is known to follow chemoattractant concentration gradients through tissue of heterogeneous pore sizes, but the dependence of migration velocity on pore size and gradient steepness is not fully understood. We enabled chemotaxis studies for at least 42 hours at confinements relevant to tissue models by two-photon polymerization of linear channel constructs with cross-sec...

The comparison of subsalt images obtained by common-azimuth migration and singlearrival Kirchhoff migration demonstrates the potential of wave-equation migration when the velocity model causes complex multipathing. Subsalt reflectors are better imaged and the typical Kirchhoff artifacts caused by severe multipathing disappear. A detailed analysis of common-azimuth images indicates that the resu...

Offset plane wave migration and common-azimuth migration are among the most promising wave-equation migration methods for efficiently imaging 3-D marine data sets. Offset plane wave migration has some computational advantages over common-azimuth migration, but common-azimuth is more accurate. Sub-salt images produced by commonazimuth migration are better focused than the corresponding images pr...

The inversion of seismic reflection data is challenging due to the oscillatory nature of the seismic data, the nonlinear relation between the data and the Earth’s model parameters, and the relative sensitivity of the different subsets of the data to the model parameters. Full-waveform inversion solves this inverse problem in the data space but is known to have shortcomings, especially because o...

In primary neurons, the oncofetal RNA-binding protein IGF2BP1 (IGF2 mRNA-binding protein 1) controls spatially restricted β-actin (ACTB) mRNA translation and modulates growth cone guidance. In cultured tumor-derived cells, IGF2BP1 was shown to regulate the formation of lamellipodia and invadopodia. However, how and via which target mRNAs IGF2BP1 controls the motility of tumor-derived cells has ...

Recruitment of leukocytes from blood to tissue in inflammation requires the function of specific cell surface adhesion molecules. The objective of this study was to identify adhesion molecules that are involved in polymorphonuclear leukocyte (PMN) locomotion in extravascular tissue in vivo. Extravasation and interstitial tissue migration of PMNs was induced in the rat mesentery by chemotactic s...

The work flow of migration velocity analysis (MVA) is widely used in seismic exploration of hydrocarbon reservoirs to refine velocity models and obtain precise information about subsurface structures. Therefore the velocity uncertainty introduced in the MVA process directly affects assessments of structural uncertainty and reservoir volumes. In order to quantify the velocity uncertainty in MVA ...

I present a simple method for computing angle-domain Common Image Gather (CIG) using prestack reverse time migration. The proposed method is an extension of the method proposed by Rickett and Sava (2001) to compute CIGs by downward-continuation shotprofile migration. I demonstrate with a synthetic example the use of the CIG gathers for migration velocity updating. A challenge for imaging both o...

Migration velocity analysis (MVA) is an approach to solve a partially linearized variant of the waveform inversion problem, i.e. linear in short scales, nonlinear in long scales. The linear inversion part is often approximated by migration in practice, which is only adjoint of linearized Born modeling operator. In this abstract, we derive the gradient formulas for short scales and long scales s...

A novel method is presented which allows the estimation of the velocity of migrating cells from positional 3HTdR labelling data in spatially organized epithelial tissues. In a continuum approach, wave-like profiles of labelling index (LI) data, which travel away from the basal layer, are followed and compared with experimental LI profiles. The method yields estimates of migration velocity, cell...