objective(s): brain edema is one of the most serious causes of death within the first few days after trauma brain injury (tbi). in this study we have investigated the role of shilajit on brain edema, blood-brain barrier (bbb) permeability, intracranial pressure (icp) and neurologic outcomes following brain trauma.   materials and methods: diffuse traumatic brain trauma was induced in rats by dr...

We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50-60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron loss. Because microglial activation can worsen brain damage after a concussive event and because mi...

Purpose Mild traumatic brain injury (TBI) is common in children. The aim of this study was to identify clinical predictors of intracranial injuries on computed tomography (CT) in infants younger than 2 years old with mild TBI, which allow reducing number of imaging. Results Of 214 enrolled infants with complete data, 30 (5.8%) sustained intracranial injuries. Younger age in months, severe inj...

Traumatic brain injury (TBI) is a frequent and clinically highly heterogeneous neurological disorder with large socioeconomic consequences. TBI severity classification, based on the hospital admission Glasgow Coma Scale (GCS) score, ranges from mild (GCS 13-15) and moderate (GCS 9-12) to severe (GCS ≤ 8). The GCS reflects the risk of dying from TBI, which is low after mild (∼1%), intermediate a...

Comprehensive reviews of neurocognitive outcomes following mild, uncomplicated traumatic brain injury (TBI) in children have shown minimal effects on neurocognition, especially in methodologically rigorous studies. In this study, we report longitudinal (1, 6, and 12 months post injury) results in four domains of neurocognitive functioning in a large sample of children with mild TBI (n = 124, ag...

traumatic brain injury (tbi) is caused by rapid deformation of the brain, resulting in a cascade of pathological events and ultimately neurodegeneration. in vitro models of tbi can help us to describe the pathobiological mechanisms. in vitro models of brain injury support a platform for performing repeatable, well-controlled, environmentally isolated experiments. other advantages of in vitro mo...

Introduction Traumatic brain injury (TBI) is amongst the leading causes of morbidity and mortality worldwide. The unprecedented emergence COVID-19 has mandated neurosurgeons to limit viral spread spare hospital resources whilst trying adapt management plans for TBI. We aimed characterize how this affects decision-making on TBI drive strategies cope with future expected waves.Methods Retrospecti...

OBJECTIVE Clinical observations report excessive sleepiness immediately following traumatic brain injury (TBI); however, there is a lack of experimental evidence to support or refute the benefit of sleep following a brain injury. The aim of this study is to investigate acute post-traumatic sleep. METHODS Sham, mild or moderate diffuse TBI was induced by midline fluid percussion injury (mFPI) ...

Traumatic brain injury (TBI) refers to a broad range of neurological, cognitive and emotional factors that result from the application of a mechanical force to the head. Mechanical force can be applied on a continuum from none to very severe, and the extent of brain injury is related to the severity of this force. A review of the literature reveals that, while considerable research has been don...

conclusions a long-term longitudinal study encompassing integrated research is needed to fully understand the traumatic experiences of caregivers. unless research on tbi or dai trauma is given its proper attention, the burden of trauma and injury on societies will continue to exacerbate globally. context as with care giving and rehabilitation in chronic illnesses, the concern with traumatic bra...