Phytoconstituents have been used in medicine science since ancient times due to their various pharmacological actions. But most of them (like flavanoids, terpenoids) are low in lipid solubility and have large molecular size due to complex multiple ring structure, causing poor absorption and poor bioavailability via oral route. The phytosome system of drug delivery results in increased bioavaila...

Use of herbal drugs in the treatment of liver diseases has a long tradition, especially in Eastern medicine. Standardization has been a problem, and randomized, placebo-controlled clinical trials to support efficacy are lacking. Some herbal extracts promoted for gastrointestinal or biliary disorders contain potent hepatotoxic alkaloids and are harmful. However, some of these extracts have yield...

Despite increasing recognition of potential untoward interactions between herbal products and conventional medications, a standard system for prospective assessment of these interactions remains elusive. This information gap was addressed by evaluating the drug interaction liability of the model herbal product milk thistle (Silybum marianum) with the CYP3A probe substrate midazolam. The inhibit...

Seven pure flavonolignans were isolated from an extract of milk thistle [Silybum marianum (L.) Gaertn (Asteraceae)], by semipreparative reverse-phase HPLC, and identified based on spectroscopic and LC-MS=IT-TOF data. All seven compounds were screened as potential antitumor-promoting agents by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)induced Epstein-Barr virus earl...

in order to evaluate the effects of organic, biological and chemical fertilizers on yield and yield components of milk thistle (silybum marianum l.), an experiment was conducted at the research station of ferdowsi university of mashhad based on complete randomized block design with three replications and six treatments during year 2007. treatments included inoculated seeds with azotobacter, com...

Insect-mediated indirect interactions between native plant species recently have been shown to be important determinants of plant performance in a number of ecological communities. However, the potential indirect effects of exotic plant invasion on native plant species are not well understood. We examined whether the presence or proximity of the targeted exotic weed, musk thistle, influences th...

Extracts from the seeds of milk thistle, Silybum marianum, are known commonly as silibinin and silymarin and possess anticancer actions on human prostate carcinoma in vitro and in vivo. Seven distinct flavonolignan compounds and a flavonoid have been isolated from commercial silymarin extracts. Most notably, two pairs of diastereomers, silybin A and silybin B and isosilybin A and isosilybin B, ...

The results of studies milk thistle productivity depending on soil and climatic conditions, doses timing mineral fertilizers, microelements, growth stimulants, plant protection products are presented. It was revealed that the formation assimilation apparatus biomass is directly related to regime nutrition, treatment seeds, crops with stimulants products. maximum leaf area (48.0 thousand m2/ha) ...