Mutations in adenomatous polyposis coli (APC) disrupt regulation of Wnt signaling, mitosis, and the cytoskeleton. We describe a new role for APC in the transport of mitochondria. Silencing of wild-type APC by small interfering RNA caused mitochondria to redistribute from the cell periphery to the perinuclear region. We identified novel APC interactions with the mitochondrial kinesin-motor compl...

Introduction: Leptin is a critical metabolic signal linking nutrition and reproductive functions. Leptin receptors are expressed in germ cells, Sertoli and Leydig cells. Oxidative stress increases sperm DNA damages. Nitric oxide is a free radical, produced by most cells via Nitric Oxide (NO) synthase and plays stimulatory and inhibitory roles on cells. Physiological concentrations of NO are ess...

Background Levels of serum gonadotropins have direct effects on testicular functions and spermatogenesis. Assessment of levels of serum gonadotropins from fathered subjects and infertile patients indicates wide range diversity. In this study, we tried to find out whether the levels of seminal FSH and LH affect the parameters of seminal fluid analysis (SFA) and if there is any correlation betwee...

the aim of this study was to investigate the comparison between some seminal plasma parameters and age of the bull. concentrations of various biochemical parameters like fructose, glucose, total proteins, albumin and inorganic ions including na, k and cl ions of seminal plasma of breeding sahiwal bulls of different ageswere assessed. methods: 40sahiwal bullsdivided into 4 age groups.semen (2ml ...

verbs Richard Power Department of Computing Open University Milton Keynes MK7 6AA, UK [email protected]