The study was designed to evaluate the efficacy and safety of an herbal extract of Yunnan Baiyao formulated in toothpaste as an alternative therapy for minor RAS. A randomized, double-blind, placebo-controlled clinical trial (from March 2010 to March 2011) was conducted on a cohort of 227 minor RAS patients. The toothpaste containing Yunnan Baiyao was used twice daily as part of the patient's r...

Background: Aphthous ulceration is a common and painful problem. This study was conducted to evaluate the therapeutic effect of local application of trichloroacetic acid and hydrogen peroxide for aphthous ulcers minor. Methodology: This was a double blind controlled study; conducted at Al-Mawanee and Basrah General Hospital. Patients with aphthous ulcers minor were enrolled in this study betwee...

Purpose PFAPA is an autoinflammatory syndrome of childhood characterized by recurrent attacks of fever, aphthous stomatitis, pharyngitis and adenitis. The underlying immune disorder is poorly understood, albeit activation of Th1 related cytokines has been observed. We aimed to compare concentration of proinflammatory cytokines and selected chemokines in PB during and between febrile episodes in...

Introduction Periodic Fever, Aphthous stomatitis, Pharyngitis and Adenitis (PFAPA) syndrome is an autoinflammatory disorder of childhood and little is known about the underlying etiology. While mutations involving the IL-1 pathway have been identified in other recurrent fever disorders, including TNF-receptor associated periodic syndrome (TRAPS) and cryopyrin-associated periodic syndrome (CAPS)...

Methods by using the Delphi and Nominal Group Technique, we started an initial phase of three following e-mail surveys. In the first survey, clinicians/biologists or other health professionals working in the field of autoinflammation were asked to identify the variables that they consider as important, in the current clinical practice, for the diagnosis of patients with PFAPA. This survey was o...

Background: Aphthous ulcer is seen to be one of the most commonly occurring ailments found among patients that dentists may come across on a daily basis. Taking into consideration agents have been used for treatment aphthous stomatitis, it would seem advisable apply agent safest and has least toxic properties can bring about symptomatic relief applied topically. These days, there are few reliab...