يفكي هنأ نيبن ،ثحبلا اذه يف ةيقفأ حئارش تاطاقسإ هيمسن ام لثم باسحلا ةلهس ملاعم مادختسا ايلآ ةعوبطملا فورحلا ىلع يئوضلا فرعتلا ةلأسم ةءافكب لحت يكل ةيسأرو . ةرجش مادختساب فرعتلا متي حاجنلا لدعم ةدايزل ىرخأ تافاضإ عم ةدمعأو فوفص فذحو ميعنتو عوجر تايلآب ةموعدم رارق . و مدختسن ماظنلا بيردتل طخ نم زومر Times New Roman . دق فذحلاو ميعنتلاو عوجرلا ليعفت نإ لاًدعم ققح حجان اً زواجت 98 % نم لقأ فرعت نمزب ...

It is evident that the accumulation of periodontal pathogens over the teeth surface triggers periodontitis; however, its aggravation and severity depend on other elements such as environmental factors, systemic health and the host genetic and/or epigenetic background. To address this issue, we investigated the association of two genetic polymorphisms placed on promoter region of SOCS1 gene with...

STATs are constitutively activated in several malignancies. In primary mediastinal large B-cell lymphoma and Hodgkin lymphoma (HL), inactivating mutations in SOCS1, an inhibitor of JAK/STAT signaling, contribute to deregulated STAT activity. Based on indications that the SOCS1 mutations are caused by the B cell-specific somatic hypermutation (SHM) process, we analyzed B-cell non-HL and normal B...

AIM To investigate the role of suppressor of cytokine signaling 1 (SOCS1) in regulating MET-mediated invasive potential of hepatocellular carcinoma (HCC) cells. METHODS Stable derivatives of mouse (Hepa1-6) and human (hep3B, HepG2) HCC cell lines expressing SOCS1 or control vector were evaluated for their ability to migrate towards hepatocyte growth factor (HGF) in the transwell migration ass...

Human T cell leukemia virus type 1 (HTLV-1) inhibits host antiviral signaling pathways although the underlying mechanisms are unclear. Here we found that the HTLV-1 Tax oncoprotein induced the expression of SOCS1, an inhibitor of interferon signaling. Tax required NF-κB, but not CREB, to induce the expression of SOCS1 in T cells. Furthermore, Tax interacted with SOCS1 in both transfected cells ...

Suppressor of cytokine signaling 1 (SOCS1) has long been thought to block type I interferon signaling. However, IFN-λ, a type III IFN with limited receptor expression in hepatic cells, efficiently inhibits HCV (Hepatitis C virus) replication in vivo with potentially less side effects than IFN-α. Previous studies demonstrated that type I and type III activated Janus kinase/signal transducer and ...

Bone metabolism and the immune system have a correlative relationship, and both are controlled by various common cytokines, such as IFNs and ILs, produced in the bone microenvironments. The suppressor of cytokine signaling-1 (SOCS1) and SOCS3 are negative regulators of such cytokines. Although SOCSs are shown to be induced during osteoclast differentiation, their physiological roles in osteocla...

Recognizing TimeML events and identifying their attributes, are important tasks in natural language processing (NLP). Several NLP applications like question answering, information retrieval, summarization, and temporal information extraction need to have some knowledge about events of the input documents. Existing methods developed for this task are restricted to limited number of languages, an...

In this study, Four Wave Mixing (FWM) characteristics in photonic crystal fibers are investigated. The effect of channel spacing, phase mismatching, and fiber length on FWM efficiency have been studied. The variation of idler frequency which obtained by this technique with pumping and signal wavelengths has been discussed. The effect of fiber dispersion has been taken into account; we obtain th...

يمومع باي تيعقوم متسيس كي تقد 3 رد متسيس وردوخ يربوان ياه يم ريثأت يفلتخم لماوع زا زا تـسا مزلا لـيلد نيمه هب و دريذپ شور دومن هدافتسا وردوخ هدش نييعت تيعقوم رد تقد شيازفا تهج هشقن قيبطت ياه . متسيس رد هشقن قيبطت وردوـخ يربواـن ياـه دراد هدهع رب ار رهش هشقن يوررب وردوخ يلعف تيعقوم نييعت هفيظو . رد هـشقن قيبطت هلأسم لح يارب يبيكرت متيروگلا كي هلاقم نيا متسيس رد يم داهنشيپ وردوخ يربوان يا...