نتایج جستجو برای: miru
تعداد نتایج: 397 فیلتر نتایج به سال:
The fi rst genetic sequencing of Mycobacterium tuberculosis was a momentous achievement that required years of painstaking eff ort and substantial funding. It is remarkable that 15 years later, advances in laboratory techniques and informatics have enabled whole-genome sequencing to be done for hundreds of M tuberculosis isolates, making this information available for epidemiological studies. T...
BACKGROUND The Philippines is designated as one of the high tuberculosis (TB) burden countries by WHO. We conducted a molecular epidemiologic analysis of Mycobacterium tuberculosis isolates collected from patients consulting at the health clinics in the city of Santa Rosa, Laguna, a suburban community in the Philippines. METHODS A total of 116 M. tuberculosis isolates were characterized and g...
Abstract Background Tuberculosis remains a serious public health concern globally. The enormous social, economic, and impacts of the diseases are attributed to lack updated data on prevalence, geospatial distribution, population structures, genotypic variants circulating M. tuberculosis . Methods Structured questionnaire, mycobacterial culture, standard 24-Mycobacterial Interspersed Repeated Un...
Molecular surveillance of multidrug-resistant tuberculosis (MDR-TB) using 24-loci MIRU-VNTR in the European Union suggests the occurrence of international transmission. In early 2014, Austria detected a molecular MDR-TB cluster of five isolates. Links to Romania and Germany prompted the three countries to investigate possible cross-border MDR-TB transmission jointly. We searched genotyping data...
Infection and transmission of multidrug-resistant Mycobacterium tuberculosis (MDR-Mtb) and extensively drug-resistant M. tuberculosis (XDR-Mtb) is a serious health problem. We analyzed a total of 1,110 Mtb isolates in Osaka Prefecture and neighboring areas from April 2000 to March 2009. A total of 89 MDR-Mtb were identified, 36 (48.5%) of which were determined to be XDR-Mtb. Among the 89 MDR-Mt...
This study was carried out in order to investigating the effect of travelling on the transmission of tuberculosis from high- to low-burden TB countries. Mycobacteria samples isolated from patients of distinct and relatively co-related countries (Azerbaijan Republic and Tabriz [located in the northwest of Iran]) were analyzed through 15 loci MIRU-VNTR typing method. PCR was done using special pr...
This study shows the benefit of spoligotyping coupled to mycobacterial interspersed repetitive-unit (MIRU) typing to pinpoint circulating Mycobacterium tuberculosis genotypes in Guadeloupe, Martinique, and French Guiana. We hereby propose reduced 4-locus and 6-locus subsets for LAM and Haarlem lineage strains that predominate in South America and the Caribbean, retaining 99.35% and 99.64% of th...
1. Abstract 2. Introduction 3. Genotyping methods 3.1. Genetic markers 3.1.1. Insertion sequences 3.1.2. Short repetitive DNA sequences 3.2. Restriction fragment length polymorphism analysis 3.2.1. IS6110 RFLP analysis 3.2.2. PGRS RFLP analysis 3.3. PCR-based typing 3.3.1. Mixed-linker PCR 3.3.2. Spoligotyping 3.3.3. VNTR and MIRU-VNTR typing 3.4. Comparison of genotyping methods 4. Molecular e...
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