BACKGROUND Mitral-valve prolapse has been described as a common disease with frequent complications. To determine the prevalence of mitral-valve prolapse in the general population, as diagnosed with the use of current two-dimensional echocardiographic criteria, we examined the echocardiograms of 1845 women and 1646 men (mean [+/-SD] age, 54.7+/-10.0 years) who participated in the fifth examinat...

BACKGROUND The outcome of mitral valve prolapse (MVP) is controversial, with marked discrepancies in reported complication rates. METHODS AND RESULTS We conducted a community study of all Olmsted County, Minn, residents first diagnosed with asymptomatic MVP between 1989 and 1998 (N=833). Diagnosis, motivated by auscultatory findings (n=557) or incidental (n=276), was always confirmed by echoc...

Abstract Background Mitral valve prolapse (MVP, MIM 157700) is a very common cardiac disorder occurring in 2.4% of the general population. MVP characterized by myxomatous degeneration resulting thickening, prolapsing and regurgitation. results mitral regurgitation, arrhythmias, bacterial endocarditis, congestive heart failure sudden death. Familial studies suggest an autosomal dominant mode inh...

BACKGROUND A new quadricusp stentless mitral bioprosthetic valve (QMV) is evaluated and compared with current standards. METHODS AND RESULTS Since August 1997, 67 patients were prospectively evaluated: 23 patients received a QMV, 23 had mitral valve repair (MVR), and 21 received conventional mitral valve replacement (MVP). Patient age was 69+/-8, 64+/-10, and 62+/-9 years for QMV, MVR, and MV...

It is known that rheumatic heart disease frequently results in isolated mitral regurgitation without concomitant mitral stenosis, especially in countries with a high prevalence of rheumatic fever. However, more recent surgical pathologic data also have demonstrated a high incidence of mitral valve prolapse in cases of rheumatic heart disease, which suggests that rheumatic fever may be a cause o...

What is Infective Endocarditis? The hallmark of infective endocarditis is an entity called the vegetation — a collection of microorganisms, platelets, and thrombi that adhere to parts of the endocardium like valve leaflets and any defects in typical endocardial anatomy (septal defects, etc.). The causative agent can be bacterial, fungal, or viral, but most commonly it is Staphylococcus aureus i...

To ascertain the effects of surgical closure of atrial septal defect on left ventricular geometry and degree of mitral prolapse, 14 patients with atrial septal defect were studied by cross-sectional and M-mode echocardiography preoperatively and 7 days postoperatively. Seven of the 14 patients (50%) had mitral valve prolapse preoperatively by cross-sectional echocardiography. To quantitate the ...

1 Reid J. Mid-systolic clicks. S African Med J 1961; 35: 353 2 Barlow J, Pocock W, Marchand P, et al. The significance of late systolic murmurs. Am Heart J 1963; 66:443-52 3 Markiewicz W, Stoner J, et al. Mitral valve prolapse in one hundred presumably healthy young females. Circulation 1976; 53:464-73 4 Procacci P, Savran S, et al. Prevalence of clinical mitral valve prolapse in 1169 young wom...

Mitral annulus disjunction (MAD) is an abnormal insertion of the flexion line mitral into atrial wall. The presents a separation (disjunction) between posterior leaflet–atrial wall junction and left ventricular myocardial crest.1 MAD was first described more than 30 years ago in autopsy study reportedly related to valve prolapse (MVP) 92% cases.2 Since then, several studies have been conducted,...