amphiphilic cationic micelles have recently attracted much attention as non-viral vector. in the current study the retinoic acid-g-chitosan (ra-chitosan) micelles have been used as novel gene carriers. uptake of micelles, condensation ability and transfection efficiency of micelle–dna complexes (miceplexes) in the presence or absence of serum had been investigated on hela and hepg2 cell lines. ...

In this paper we describe enzyme-responsive fluorogenic micellar nanoparticles with detectable spectrophotometric properties unique to the particles and their aggregated state. These micelles are assembled from peptide-polymer amphiphiles (PPAs) labeled with either fluorescein or rhodamine. This is achieved by labelling otherwise similar block copolymer amphiphiles with each of the dyes. When m...

The mixed micellization behaviour of amitriptyline hydrochloride (AMT) with ionic liquid (IL) 1-methyl-3-octylimidazolium hydrochloride, [C8mim][Cl], have been investigated using electrical conductivity, at different temperatures. The non-ideal behaviour (i.e., synergistic interaction) of AMT-[C8mim][Cl] binary mixtures, explained by the deviations in critical micelle concentration (cmc) from i...

The mixture system of two classic surfactants cationic and non-ionic – C16TAB (hexadecyltrimethylammonium bromide)+TX-100(p-(1,1,3,3-tetramethyl) poly(oxyethylene) in heavy water solutions was investigated at temperatures 30, 50, 70 for compositions 1:1, 2:1, 3:1 by the small-angle neutron scattering(SANS) method on spectrometer (‘YuMO’) at the IBR2 pulsed neutron source at FLNP, JINR in Dubna ...

Here, we developed Pluronic® P123/F127 (poloxamer) mixed micelles for the intravenous delivery of the anticancer drug sorafenib (SRB) or its combination with verteporfin (VP), a photosensitizer for photodynamic therapy that should complement well the cytotoxicity profile of the chemotherapeutic. SRB loading inside the core of micelles was governed by the drug:poloxamer weight ratio, while in th...

Self-assembled, lipid-based micelles, such as those formed by the short-chain phosphocholine, dihexanoylphosphatidylcholine (2C6PC), are degraded pancreatic enzyme, phospholipase A2 (PLA2). Degradation yields 1-hexanoyl-lysophosphocholine (C6LYSO) and hexanoic acid (C6FA) products. However, little is known about behavior of these products during after degradation 2C6PC. In this work, a combinat...

Capillary electrophoresis (CE) was used to study the polydispersity of TX-100/SDS and C12E8/SDS micelle systems. Compared with other techniques, CE provides more specific and graphically detailed information on the compositional polydispersity of such micellar systems. Clear evidence of the coexistence of micelles rich in either nonionic or anionic component has been obtained. This coexistence ...

Sodium dodecyl sulfate (SDS) surfactants form micelles when dissolved in water. These are formed of a hydrocarbon core and hydrophilic ionic surface. The small-angle neutron scattering (SANS) technique was used with deuterated water (D2O) in order to characterize the micelle structure. Micelles were found to be slightly compressed (oblate ellipsoids) and their sizes shrink with increasing tempe...

The binding of protein kinase C (PKC) to pyrene-labeled diacylglycerol (pDG) has been studied in a mixed micellar system by monitoring resonance energy transfer from excited tryptophans to pyrene with time-correlated single photon counting. The average lifetime of the excited state of the tryptophans in PKC showed a clear dependence on the mole percentage pDG in micelles in contrast with pyrene...