The Tyr-SV40E transgenic mouse model of malignant skin melanoma has been used here to generate melanomas in genetically identical (C57BL/6) mice for analysis of the plasminogen activator (PA) system during tumor development and progression. Twenty-two melanocytic lesions were examined by in situ zymography for PA activity and by immunohistochemistry for concomitant visualization of PA proteins;...

The layered model of Sanders, et al. (1997) is a value-added assessment model that uses multivariate longitudinal mixed model methodology. This model, whose advantages are reemphasized here, has been criticized for its complexity and lack of transparency. The main purpose of this paper is to provide more transparency for this model by comparing it to three sub-models which provide a decompositi...

Als Beispiel einer interaktiven Mixed Reality Umgebung beschreiben wir den „Sensoric Garden“, sieben während eines Festivals gezeigte Installationen. Da solche Ereignisse sich nicht in Bezug auf Benutzbarkeit oder Effektivität bewerten lassen, benötigen wir andere Kriterien, um die Attraktivität der Installationen für Besucher zu erklären. Konzepte aus der Debatte um Interaktionsdesign und Inte...

6 We consider the problem of clustering time dependent data. The model is 7 a mixture of regressions, with variance-covariance matrices that are allowed 8 to vary within the extended linear mixed model family. We discuss appli9 cations to biomedical data and analyze two longitudinal data sets: one on 10 patients with delirium, and the other on mosquito gene expression following 11 infection. 12

We review and integrate existing literature on perceptions of humanness and dehumanization. Synthesizing three independent lines of research (Haslam’s two senses of humanness, mind perception theory, the stereotype content model), we provide a taxonomy of different phenomena (e.g., animalistic and mechanistic dehumanization, objectification, demonization, etc.) that all fall under the broad cat...

This paper presents novel approaches for generating sequencing rules for the car sequencing (CS) problem in cases of two and multiple processing times per station. The CS problem decides on the succession of different car models launched down a mixed-model assembly line. It aims to avoid work overloads at the stations of the line by applying so-called sequencing rules, which restrict the maximu...

Profile monitoring is a relatively new technique in quality control used when the product or process quality is best represented by a profile (or a curve) at each time period. The essential idea is often to model the profile via some parametric method and then monitor the estimated parameters over time to determine if there have been changes in the profiles. Previous modeling methods have not i...

The authors are to be congratulated for an interesting paper which highlights the need for more formal procedures on the assessment of goodness of fit in the area of mixed models. The authors give a comprehensive overview of diagnostic techniques and goodness-of-fit tests for random effects in mixed models and propose a number of new nonparametric tests with omnibus character. Some of them are ...

It is shown that a method of robust estimation in a two way crossed classification mixed model, recently proposed by Bednarski and Zontek (1996), can be extended to a more general case of variance components model with commutative a covariance matrices.