The current study examines the possibility that the TCR repertoire of L3T4-, Lyt-2- cells in lpr/lpr mice is enriched for self-reactive specificities. T cells utilizing V beta 17a and V beta 8.1 gene products have been shown to be clonally eliminated in nonautoimmune mice expressing I-Ek and Mlsa/H-2k, respectively, because of their potential self reactivity. We quantitated these V beta specifi...

In opinion mining of product reviews, one often wants to produce a summary of opinions based on product features/attributes. However, for the same feature, people can express it with different words and phrases. To produce an effective summary, these words and phrases, which are domain synonyms, need to be grouped under the same feature. Topic modeling is a suitable method for the task. However...

In this paper, we define an F0 quantization scheme for a very low bit rate speech coder based on HMM (Hidden Markov Model). In the coding system, the encoder carries out phoneme recognition, and transmits phoneme indices, state durations and F0 information to the decoder. In the decoder, phoneme HMMs are concatenated according to the phoneme indices, and a sequence of mel-cepstral coefficient v...

One of the key requirement in image guided surgery (IGS)/ computer aided surgery (CAS) planning is accurate segmentation of the images concerned. It is also a challenging issue for the purpose of image analysis and understanding in general, and surgical intervention involving image guided surgery (IGS) in particular. Thus, in this paper, a technique employing two-stage segmentation in which one...

Abstract We present a live demo of Idlak Tangle, a TTS extension to the ASR toolkit Kaldi [1]. Tangle combines the Idlak front-end and newly released MLSA vocoder, with two DNNs modelling respectively the units duration and acoustic parameters, providing a fully functional end-to-end TTS system. The system has none of the licensing restrictions of currently available HMM style systems, such as ...

Halobacteria require high NaCl concentrations for growth and are the dominant inhabitants of hypersaline environments above 15% NaCl. They are well-documented to be highly recombinogenic, both in frequency and in the range of exchange partners. In this study, we examine the genetic and genomic variation of cultured, naturally co-occurring environmental populations of Halobacteria. Sequence data...

Gut intraepithelial lymphocytes (IEL) contain two independent T cell receptor a/#+ T cell populations, with different V# repertoires . In DBA/2 mice (Mlsa, IE'), the C1341 and heterodimeric alO CD8+ thymodependent T cell pool shows the same deletion of V#6, 8.1, and 11 + cells as found in peripheral lymphoid organs. In contrast, such deletions are not observed in the pool of IEL bearing homodim...

As various new sibling species within the Scedosporium spp. have been described recently, this study was conducted to investigate distribution and antifungal susceptibility profiles of the different species of Scedosporium spp. in China. Twenty-one clinical strains of Scedosporium from China and two strains from Japan were reidentified by MLSA. The analysis included BT2, CAL, RPB, SOD, and ACT ...

Mobile location sensing applications (MLSAs) represent an emerging genre of applications that exploit Global Positioning System (GPS) technology and facilitate location-based services. The design of MLSAs must incorporate a tradeoff between information accuracy and energy efficiency because GPS technology is energy expensive and unaffordable for most MLSA platforms, which are battery-powered an...