GDC-0834, a Bruton's tyrosine kinase inhibitor investigated as a potential treatment of rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis such that no measurable levels of this compound were detected in human circulation after oral administration. In vitro studies in human liver cytosol determined that GDC-0834 (R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopipe...

The large neighborhood search (LNS) framework introduced by Shaw [11] provides a powerful hybridization of Local Search (LS) and Constraint Programming (CP). The idea of LNS is to combine the expressiveness of CP and the efciency of Local Search (LS) without requiring any meta-heuristic. LNS consists in improving a best-so-far solution by iteratively relaxing it and optimizing this solution usi...

The widespread use of model driven engineering in the development of software-intensive systems, including highintegrity embedded systems, gave rise to a “Tower of Babel” of modeling languages. System architects may use languages such as OMG SysML and MARTE, SAE AADL or EAST-ADL; control and command engineers tend to use graphical tools such as MathWorks Simulink/Stateflow or Esterel Technologi...

The utilization of organosulfonates as carbon sources by aerobic or nitrate-reducing bacteria usually involves a measurable, uncharacterized sulfite dehydrogenase. This is tacitly assumed to be sulfite : ferricytochrome-c oxidoreductase [EC 1.8.2.1], despite negligible interaction with (eukaryotic) cytochrome c: the enzyme is assayed at high specific activity with ferricyanide as electron accep...

Introducción. Los quistes de duplicación duodenal son malformaciones raras, que ocurren durante el desarrollo embriológico del tracto gastrointestinal. Caso clínico. Se presenta caso un niño tres años, con cuadro clínico dolor abdominal, náuseas y vómitos. La ecografía la tomografía computarizada informaron una imagen quística entre hígado, riñón derecho colon. Resultados. realizó laparoscopia ...

In contrast to its parent strain, transposon Tn5-Mob insertion mutant HB6 of the facultative chemoautotroph Ralstonia eutropha was unable to grow organoautotrophically on formate and exhibited no activity of Mo-dependent, membrane-bound formate dehydrogenase (M-FDH) when cultivated mixotrophically on fructose plus formate. The activity of another molybdoenzyme, the soluble, NAD+-linked formate ...

Practical knowledge on the design and application of multiobjective evolutionary algorithms (MOEAs) is available but well-founded theoretical analyses of the runtime are rare. Laumanns, Thiele, Zitzler, Welzel and Deb (2002) have started such an analysis for two simple mutation-based algorithms (SEMO and FEMO) for combinatorial optimization problems. These algorithms search locally in the neigh...


 Este trabajo describe los efectos del probiótico Saccharomyces cerevisiae sobre el área, número de criptas Lieberkühn en duodeno y yeyuno, producción moco ambas secciones intestinales. Fueron empleados tejidos un total 27 individuos, clasificados grupo control – GC (n=12) suplementado con probióticos GP (n=15). Los resultados revelaron que grupos suplementados presentaron una mayor ampli...

An organism’s metabolome is the cataloguing of the entire set of metabolites found in the organism. It is dynamic and thus just a snapshot of the processes going on in the organism at one specific time point. When combined with other ‘‘omics’’ data, a more complete understanding of the organism emerges (Fiehn et al., 2000). However, several technical challenges to obtaining a metabolomic profil...

Tungsten (W) is a rare heavy metal, widely used in a range of industrial, military and household applications due to its unique physical properties. These activities inevitably have accounted for local W accumulation at high concentrations, raising concerns about its effects for living organisms. In plants, W has primarily been used as an inhibitor of the molybdoenzymes, since it antagonizes mo...