The Personal Distributed Environment (PDE) is a new concept arising in personal communications beyond 3G (B3G). This paper briefly describes the environment, surveys the protocols available to provide PDE authentication, and assesses their suitability for adaptation to the PDE.

Ventricular muscle contains a low Km, cyclic AMP-specific form of phosphodiesterase (PDE III), which is believed to represent the site of action for several of new cardiotonic agents including imazodan (CI-914), amrinone, cilostamide, and enoximone. However, species differences in the inotropic response to these agents have raised questions about the relationship between PDE III inhibition and ...

Environmental carcinogens, such as polycyclic aromatic hydrocarbons (PAHs), require metabolic activation to DNA-reactive metabolites in order to exert their tumorigenic effects. Benzo[a]pyrene (B[a]P), a prototypic PAH, is metabolized by cytochrome P450 (P450) 1A1/1B1 and epoxide hydrolase to (-)-B[a]P-7,8-dihydro-7,8-diol (B[a]P-7,8-dihydrodiol). B[a]P-7,8-dihydrodiol then undergoes further P4...

Excessive mesangial cell (MC) proliferation is a hallmark of many glomerulopathies. In our recent study on cultured rat MC (Matousovic, K., J.P. Grande, C.C.S. Chini, E.N. Chini, and T.P. Dousa. 1995. J. Clin. Invest. 96:401-410) we found that inhibition of isozyme cyclic-3',5'-nucleotide phosphodiesterase (PDE) type III (PDE-III) suppressed MC mitogenesis by activating cAMP-dependent protein k...

We derive the full kinetic equations describing evolution of probability density distribution for a structured population such as cells distributed according to their ages and sizes. The "sizer-timer" model incorporates both demographic individual cell growth rate stochasticities. Averages taken over densities obeying can be used generate second order PDE that stochasticity. On other hand, marg...

In this paper we introduce a new method for defining preconditioners for the iterative solution of a system of linear equations. By generalizing the class of modified preconditioners (e.g. MILU), the interface probing, and the class of preconditioners related to the Frobenius norm minimization (e.g. FSAI, SPAI) we develop a toolbox for computing preconditioners that are improved relative to a g...

Counterfeit phosphodiesterase-5 inhibitors (PDE-5i) are an increasing problem. Already in widespread use, the market for PDE-5i is steadily growing as the population ages. Counterfeiters are taking advantage of this growing market by developing illicit and counterfeit PDE-5i products. Many factors are contributing to the rapid growth of the illicit market, such as the low risk of prosecution, p...

OBJECTIVES With the introduction of sildenafil citrate (Viagra), the concept of phosphodiesterase (PDE) inhibition has gained tremendous interest in the field of urology. Cyclic nucleotide second messengers cGMP and cAMP have been assumed to be involved in the control of the normal function of the prostate. The aim of the present study was to evaluate by means of immunohistochemistry the expres...

The amino acid sequences of all known cGMP-binding phosphodiesterases (PDEs) contain internally homologous repeats (a and b) that are 80-90 residues in length and are arranged in tandem within the putative cGMP-binding domains. In the bovine lung cGMP-binding, cGMP-specific PDE (cGB-PDE or PDE5A), these repeats span residues 228-311 (a) and 410-500 (b). An aspartic acid (residue 289 or 478) tha...

We present a novel integrable non-autonomous partial differential equation of the Schwarzian type, i.e. invariant under Möbius transformations, that is related to the Korteweg-de Vries hierarchy. In fact, this PDE can be considered as the generating equation for the entire hierarchy of Schwarzian KdV equations. We present its Lax pair, establish its connection with the SKdV hierarchy, its Miura...