A critically evaluated database of human intestinal absorption for 648 chemical compounds is reported in this study, among which 579 are believed to be transported by passive diffusion. The correlation analysis between the intestinal absorption and several important molecular properties demonstrated that no single molecular property could be used as a good discriminator to efficiently distingui...

The results of boxed dynamics (BXD) fully atomistic simulations of protein unfolding by atomic force microscopy (AFM) in both force clamp (FC) and velocity clamp (VC) modes are reported. In AFM experiments the unfolding occurs on a time scale which is too long for standard atomistic molecular dynamics (MD) simulations, which are usually performed with the addition of forces which exceed those o...

The ultrasonic amlfiiLudc absorl)liou coelhcient has Iveen determined in aqueous solutions of four molecular weights (73 000, 186 000, 370 000, and 2 {DO 000) of dextran, a linear • (! --• 6) anhydroglucoae polysaccharide of biological origin, over the frequency range 3-69 Mc/sec at 22øC. It is found that the concentrationfree absorption spectrum exhibits a remarkable similarit)' to that of aqu...

Oral absorption of compounds depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal absorption. Despite this, the nature and exact characteristics of the relationship between these parameters are not well understood. In this stu...

Visual systems of vertebrates exhibit a striking level of diversity, reflecting their adaptive responses to various color environments. The photosensitive molecules, visual pigments, can be synthesized in vitro and their absorption spectra can be determined. Comparing the amino acid sequences and absorption spectra of various visual pigments, we can identify amino acid changes that have modifie...

UV-vis optical absorption spectra of the antitrypanocidal drug benznidazole solvated in water were measured for various concentrations. The spectra show a prominent peak around 3.80 eV, while deconvolution of the UV-vis optical absorption spectra revealed six bands centered at 3.60, 3.83, 4.15, 4.99, 5.60, and 5.76 eV. Benznidazole electronic transitions were obtained after density functional t...

We demonstrate a scheme for direct absorption imaging of an ultracold ground-state polar molecular gas near quantum degeneracy. Imaging molecules without closed optical cycling transitions is challenging. Our technique relies on photon-shot-noise-limited absorption imaging on a strong but open bound-bound molecular transition. We present a systematic characterization of this imaging technique. ...

Bats tend to have less intestinal tissue than comparably sized nonflying mammals. The corresponding reduction in intestinal volume and hence mass of digesta carried is advantageous because the costs of flight increase with load carried and because take-off and maneuverability are diminished at heavier masses. Water soluble compounds, such as glucose and amino acids, are absorbed in the small in...

We report the detection of broad (FWHM 270kms 1) H I 21 cm absorption toward the compact (<15h 1 pc) radio nucleus of the nearby powerful radio galaxy Cygnus A. The absorption corresponds to a column density of hydrogen atoms of at least 2.54 0.44 1019 Tspin cm 2. Observations of OH and H2CO yielded upper limits. While other possibilities exist, we argue that the observed H I absorption plausib...