the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...

the n-(2-benzoyl-phenyl) oxalyl derivatives are important models for studying of three-centered intramolecular hydrogen bonding in organic molecules. the quantum theoretical calculations for two crystal structures of n-(2-benzoyl-phenyl) oxalyl (compounds i and ii) were performed by density functional theory (b3lyp method and 6-311+g* basis set). from the optimized structures, geometric paramet...

background: dna extraction is one the most important steps for molecular analysis of food-borne pathogens. in this research, three methods of dna extractions from beef harboring sarcocystis spp. were compared for the quality, quantity, safety, as well as cost-effectiveness. methods: about 100 mg intersostal and diaphragm were collected from 10 slaughtered cattle. after ensuring their contaminat...

bovine ephemeral fever (bef) is an acute epidemic disease in cattle and water buffalo, spanning tropical and subtropical zones of asia, australia, and africa. in recent years, bef has been distributed in many provinces of iran and caused economic losses. in this study the sequence encoding the g1 epitope of bovine ephemeral fever virus (befv) g glycoprotein was amplified by pcr, ligated into th...

the present report aimed to study an uncommon case of a pair of twins that presented a discordant dental phenotype. family investigation, clinical, radiographic examination and molecular analysis were performed in both girls. molecular analysis confirmed the monozygosity by deoxyribonucleic acid chip technology. one twin presented tooth agenesis in left upper lateral incisor and peg-shaped on t...

colletotrichum species are associated with citrus plants as pathogens, saprobes and endophytes. according to the most recent multigene phylogenetic analysis, a lot of changes were happened in the taxonomy and species delimitation in the genus colletotrichum. in this investigation, 292 colletotrichum isolates were obtained from leaves, fruits and stems of citrus species at golestan, mazandaran, ...

b1-xlaxfeo3 (x = 0.0, 0.025) crystallites were prepared by chemical solution route. xrd analysis confirmed the phase formation of the materials. thermal characterization was done by dsc-tga to confirm crystallization and thermal behavior for phase development. morphological studies by fesem showed the agglomerated nature of the ferrite and edx analysis confirmed the degree of doping. ftir studi...

introduction: the main agents of sarcocystosis in cattle as an intermediate host include s. cruzi, s. hominis and s. hirsuta. a sensitive and specific tool such as molecular-based techniques would be necessary to identify the species. case report: after collection of beef sample from yazd slaughterhouse, dna extraction was done with salting out method. the 18srrna gene as a specific target gene...

A familial reciprocal translocation associated with severe macromastia has been characterized by molecular cytogenetic and molecular analysis. Cloning of the translocation breakpoints revealed that no known gene has been disrupted by this translocation. Therefore, a position effect compromising the regulation of a still to be identified gene in the vicinity of the breakpoints can be assumed.