Disinhibitory Recruitment of NMDA Receptor Pathways in Retina 1 2 Running Head: Regulation of NMDAR activation in RGCs 3 Authors: Santhosh Sethuramanujam, Malcolm M. Slaughter. 4 Center for Neuroscience and Department of Physiology and Biophysics 5 University at Buffalo, Buffalo, NY-14214 USA 6 Corresponding Author: 7 Santhosh Sethuramanujam. 8 Department of Physiology and Biophysics, 9 124 She...

1Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612; 2Department of Biophysics and Physiology, University of Kentucky, Lexington, Kentucky 40536; 3National Resource for Computers in Life Science Education, Seattle, Washington 98115; 4Department of Biology, Wheaton College, Wheaton, Illinois 60187; 5Section of Neurobiology, Physiology, and Behavior, ...

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115; Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298; Cardiology Division, Department of Medicine, and Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver–Anschut...

Molecular Mechanisms Oliver P. Ernst,*,† David T. Lodowski,‡ Marcus Elstner, Peter Hegemann, Leonid S. Brown, and Hideki Kandori †Departments of Biochemistry and Molecular Genetics, University of Toronto, 1 King’s College Circle, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada ‡Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, 10900 Euclid...

The traditional approach to computational biophysics studies of molecular systems is brute force molecular dynamics simulations under the conditions of interest. The disadvantages of this approach are that the time and length scales that are accessible to computer simulations often do not reach biologically relevant scales. An alternative approach, which we call intuitive modeling, is hypothesi...

I n t r o d u c t i o n Developments in modern biology have been judged on their ability to provide a quantitative description of the complex and coordinated chemical processes that define living systems. The goal in most of these efforts has been to develop detailed models that allow structure-function relationships to be recognized and tested with molecular genetics. By far the most successfu...

The development of experiments capable of probing individual molecules has led to major breakthroughs in fields ranging from molecular electronics to biophysics, allowing direct tests of knowledge derived from macroscopic measurements and enabling new assays that probe population heterogeneities and internal molecular dynamics. Although still somewhat in their infancy, such methods are also bei...

G protein-coupled receptors (GPCRs) are a large, biomedically important family of proteins, and the recent explosion of new high-resolution structural information about them has provided an enormous opportunity for computational modeling to make major contributions. In particular, molecular dynamics simulations have become a driving factor in many areas of GPCR biophysics, improving our underst...

It has recently become practical to construct Markov state models (MSMs) that reproduce the long-time statistical conformational dynamics of biomolecules using data from molecular dynamics simulations. MSMs can predict both stationary and kinetic quantities on long timescales (e.g. milliseconds) using a set of atomistic molecular dynamics simulations that are individually much shorter, thus add...

This paper presents a comprehensive list of the scientific articles of Giulio Fermi (1936-1997), son of the Italian-American physicist Enrico Fermi, published between 1962 and 1997. The initial research activity of Giulio was concerned with virology and biological cybernetics while, from 1975 onward, his work was completely devoted to protein crystallography. The crystallographic research was c...