Advanced hepatocellular carcinoma is defined as liver cancer with vascular invasion or extrahepatic metastasis that is untreatable by local therapy. In Japan, hepatic arterial infusion chemotherapy (HAIC) with interferon plus 5-fluorouracil (5-FU) or a combination of low-dose 5-FU and cisplatin, referred to as low-dose FP, is administered for treating advanced liver cancer and yields favorable ...

When a cell’s DNA is damaged, the injured cells react by changing from normal to malignant cells, rather than dying or repairing the damage. Metastatic cancer is the deadliest kind of cancer since it refers to cancer that has spread to other parts of the patient’s body. The need for cancer detection techniques that are rapid, non-invasive, and accurate is growing. Cancer diagnosis, monitoring, ...

UNLABELLED The annual incidence of cancer has increased over the past 20 years, yet the 5-year relative survival rate for cancer has improved with the increasing availability of advanced therapies, including molecular targeted therapy. Cardiovascular toxicity can develop with this type of targeted therapy, which can cause serious side effects including left ventricular dysfunction, hypertension...

Blood–Brain Barrier Therapy The blood–brain barrier (BBB) is a bottleneck in the treatment of brain tumors. In article number 2203678, Liang Wang, Yinyan Lin Feng, and co-workers summarize current approaches to overcome BBB, such as use “Trojan horse” molecular modifications for deception, describe variety micro-nanocarriers targeted tumor therapy.

background: considering molecular target therapy concept in the treatment of oral squamous cell carcinoma (oscc), many attempts have been performed to introduce an effective molecular marker during recent years. several investigations have emphasized on the role of cd44 in various cancers and few studies have mentioned cd24 and cd74. the purpose of this study was to investigate the relationship...

production and approval of trastuzumab (herceptin®) for the treatment of metastatic breast cancer (mbc) was a millstone in antibody-based targeted therapy in the cancer treatment. however, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. the majority of patients who benefit from the drug acqui...

BACKGROUND Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. The outcome of HCC therapy depends on the stage of HCC. Early-stage HCC patients can be cured with radical treatment approaches, whereas no standard treatment regimens can be recommended for patients with advanced disease. SUMMARY In-depth basic research into the molecular mechanisms of ...