The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that ...

Fluoxetine inhibits the reuptake of serotonin, and dextroamphetamine enhances presynaptic release of monoamines. Although the excitatory effect of both noradrenaline and dopamine on motor behavior generally is accepted, the role of serotonin on motor output is under debate. In the current investigation, the authors evidenced a putative role of monoamines and, more specifically, of serotonin in ...

Monoaminergic projections are among the first supraspinal inputs to innervate spinal networks. Little is known regarding the role of monoamines in modulating ongoing locomotor patterns evoked by endogenous release of neurotransmitter. Here we activate a locomotor-like rhythm by electrical stimulation of afferents and then test the modulatory effects of monoamines on the frequency, pattern, and ...

Caenorhabditis elegans exhibits behavior plasticity that appears to correspond to non-associative and associative learning, and short-term and long-term memory. Recent finding revealed that evolutionally conserved molecules such as insulin, monoamines, and neuropeptides are required for the plasticity. We propose the concept of human brain operation from the C. elegans studies.

Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors. This gradually disinhibits the turnover of other monoamines like dopamine and noradrenaline that are critical for sexual desire.

antidepressant agents inhibit the neuronal reuptake of monoamines such as serotonin (5-ht), noradrenaline (na), and dopamine (da). several clinical and animal studies have advocated the use of these agents in the management of pain. in this study, therefore, the possibility of a correlation between the analgesic activity of six serotonin specific reuptake inhibitor (ssri) antidepressants and th...