The solid-state form of an active pharmaceutical ingredient (API) in an oral dosage form plays an important role in determining the dissolution rate of the API. As the solid-state form can change during dissolution, there is a need to monitor the oral dosage form during dissolution testing. Coherent anti-Stokes Raman scattering (CARS) microscopy provides rapid, spectrally selective imaging to m...

The thermotropic phase behavior of cholesterol monohydrate in water was investigated by differential scanning calorimetry, polarizing light microscopy, and x-ray diffraction. In contrast to anhydrous cholesterol which undergoes a polymorphic crystalline transition at 39 degrees C and a crystalline to liquid transition at 151 degrees C, the closed system of cholesterol monohydrate and water exhi...

This study examined the ability of purified gallbladder mucin to accelerate the nucleation of cholesterol monohydrate crystals from the cholesterol-transporting particles in supersaturated model bile. Mixed lipid micelles and cholesterol-phosphatidylcholine vesicles in supersaturated model bile were separated by Sephadex G-200 column chromatography. Mixed lipid micelles prepared by column chrom...

A novel approach was used to develop and validate a rapid, specific, accurate and precise reverse phase ultra performance liquid chromatographic (UPLC) method for the simultaneous determination of Sitagliptin phosphate monohydrate and Metformin hydrochloride in pharmaceutical dosage forms. The chromatographic separation was achieved on Aquity UPLC BEH C8 100 × 2.1 mm, 1.7 μm, column using a buf...

The purpose of this study was to examine the effects of acute creatine-monohydrate supplementation on soccer-specific performance in young soccer players. Twenty young male soccer players (16.6 +/- 1.9 years) participated in the study and were matched and allocated to 2 randomly assigned trials: ingesting creatine-monohydrate supplement (3 x 10-g doses) or placebo for 7 days. Before and after t...

BACKGROUND Use of creatine has become widespread among sportsmen and women, although there are no conclusive evidences concerning possible health risks of long-term creatine supplementation. THE AIM OF THE STUDY To investigate long-term effects of creatine monohydrate supplementation on clinical parameters related to health. METHODS Eighteen professional basketball players of the first Span...

Microcrystals of piroxicam (PRX) monohydrate with a narrow size distribution were prepared from acetone/PRX solutions by antisolvent crystallization via metallic membranes with ordered pore arrays. Crystallization was achieved by controlled addition of the feed solution through the membrane pores into a well-stirred antisolvent. A complete transformation of an anhydrous form I into a monohydrat...

Kalanchoe pinnata leaves are used in South Asia as a natural kidney stone treatment. In vitro studies were conducted supersaturated and artificial urine solutions to evaluate the antiurolithic properties of K. leaf extract on calcium oxalate monohydrate (COM) surgically extracted stones. Key organic acids present plant also examined investigate inhibition formation. Crystals harvested from diss...

The recovery of municipal solid waste incineration (MSWI) fly ash is currently considered to be the most viable solution for its management. However, in developing resource technologies, it crucial consider overall environmental impact. This study employed a life-cycle assessment (LCA) compare environmentally friendly red bricks partially utilizing MSWI as raw material with conventional bricks....

The results of physicochemical analyzes the compound CuNH 4 PO ∙ H 2 O isolated from ammophos pulp at pH 6.58 obtained by neutralization phosphoric acid containing copper sulfate as a trace element with gaseous ammonia are presented. was found to have formula [Cu (NH 3 ) (H O) HPO ]. parameters N–H bond for coordinated amino group were calculated: force constant, angle, and interatomic distance...