Freshly isolated mononuclear leukocytes have been reported to show changes in cholesterol synthesis and high-affinity degradation of low-density lipoproteins (LDL) that parallel those that occur in the liver. To examine whether hypolipidemic therapy in patients with heterozygous familial hypercholesterolemia influences cholesterol homeostasis in their mononuclear cells we assessed the effects o...

OBJECTIVES Stem cell transplant can induce vasculogenesis and improve the blood supply to an ischemic region, offering hope for chronic lower extremity ischemic diseases. Bone marrow mononuclear cells are one of the sources for stem cell transplants. We sought to observe the safety and efficacy of autologous bone marrow mononuclear cells transplant for treating critical limb ischemia. MATERIA...

the armadillo could be considered as an experimental model for leprosy studies. mycobacterium leprae main host cells are macrophages and schwann cells. however, endocytosis and germicidal activities of armadillo macrophages and monocytes have not yet been evaluated. the aim of this research was to evaluate endocytosis and nbt-reduction activities of monocyte-derived macrophages (mdm) and monocy...

introduction: the telomeric dna together with its associated  proteins protects the chromosome ends from degradation or aberrant recombination. telomerase and telomere are closely associated with  development of cancers. in this study we aim to investigate the significance of telomerase activity (ta) and telomere length (tl) in patients with acute promyelocytic leukemia (apl). methods: peripher...

The use of marrow aspirates in bone marrow transplantation. clinical evaluation. and experimental studies has prompted the present study of the functional characteristics of mononuclear cells from aspirated (iliac crest) and curettaged (rib) marrow. In this manner. the relative contribution of peripheral blood contamination of aspirated bone marrow cells in investigating and understanding marro...

Acquired resistance to Mycobacterium leprae, the etiologic agent of leprosy, crucially depends on cellular immune mechanisms. In addition to interleukin-mediated helper functions, killer mechanisms seem to be involved. This study addresses the question of how M. leprae render mononuclear phagocytes and Schwann cells, its natural targets, susceptible or resistant to killer cells. Killer activiti...

We examined human immunodeficiency virus (HIV) production in cultured mononuclear cells from 36 seropositive homosexual males. Production was detected by using an HIV p24 antigen ELISA assay in blood mononuclear cells in 54% of asymptomatic, 71% of acquired immunodeficiency syndrome (AIDS)-related complex, and 100% of AIDS patients. When the peripheral blood mononuclear cells were separated int...

background: the major immuno-modulating effects of ganoderma lucidum include mitogenicity and activation of immune effector cells such as t cells, macrophages and natural killer cells resulting in the production of cytokines. objective: the purpose of this study was to evaluate the expression of cd40 and cd80 by g. lucidum-treated human peripheral blood mononuclear cells. methods: monocytes wer...

BACKGROUND Interstitial lung diseases are characterised by the recruitment of mononuclear cells to disease sites where maturation occurs and activation products, including lysozyme (LZM), are released. Analysis of in vitro cell culture supernatants for activation products masks the functional heterogeneity of cell populations. It is therefore necessary to examine the secretion of activation pro...

background: during the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. however, there is a potential concern for malignant transformation after stem cell therapy. the aim of this study was to evaluate the development of hepatocellular carcinoma (hcc) after autologous bone marrow stem cell transplantation for liver cirrhosis. methods: all the patien...