OBJECTIVE To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection. METHODS A retrospective study was performed to identify HIV-positive individuals with acute, painful lower motor neuron diseases. RESULTS Six patients were identified with HIV and lower motor neuron disease. Two patients met the inclusion criteria of well-controlled, chr...

Motor neuron disease is a neurodegenerative disease characterized by loss of upper motor neuron in the motor cortex and lower motor neurons in the brain stem and spinal cord. Death occurs 2-4 years after the onset of the disease. A complex interplay of cellular processes such as mitochondrial dysfunction, oxidative stress, excitotoxicity, and impaired axonal transport are proposed pathogenetic ...

Spinal muscular atrophy, a common autosomal recessive motor neuron disorder, is caused by the loss of the survival motor neuron gene (SMN1). SMN2, a nearly identical copy gene, is present in all spinal muscular atrophy patients but differs by a critical nucleotide that alters exon 7 splicing efficiency. This results in low survival motor neuron protein levels, which are not enough to sustain mo...

From the Department of Surgery, Tohoku University, Faculty of Medicine, Sendai. Director : Prof. S-T. Katsura (Received for publication, February 19, 1955) Studies of E.M.G. have made a great advance recentlyl)2). It has be come evident that the E.M.G. is significant for the diagnosis of diseases on the lower motor neuron. Clinical application of E.M.G. on disease of the upper motor neuron is, ...