INTRODUCTION: Repairing the damaged nervous system is one of the greatest challenges facing regenerative medicine. Research into nervous system repair can be separated into two broad areas covering the central nervous system (CNS) and the peripheral nervous system (PNS). Damage to peripheral nerves can lead to loss of sensation, motor function and muscle weakness, but the PNS is capable of sign...

OBJECTIVES This review article aimed to present a clinical approach, emphasizing the diagnostic investigation, to children and adolescents who present in the emergency room with acute-onset muscle weakness. SOURCES A systematic search was performed in PubMed database during April and May 2017, using the following search terms in various combinations: "acute," "weakness," "motor deficit," "fla...

A 5-yr-old boy was admitted with complaints of sudden onset of weakness in both lower limbs since 4 days. There was no history of any trauma, fever, diarrhea, respiratory tract infection, exanthematous illness, unconsciousness, convulsions or tuberculosis. There was no history of similar illness in the neighborhood. The child was fully immunized. On examination, the child was afebrile, consciou...

Thenar motor unit counts were done in 19 subjects with symptoms characteristic of the carpal tunnel syndrome. Three-quarters of the patients had motor unit count estimates less than 2 SD lower limit of controls. Despite this, most did not have thenar wasting or weakness. Functional compensation by motor unit remodelling probably kept pace with motor axon loss and masked the true extent of axona...

Background: Spinal muscular atrophy (SMA) is a genetic motor neuron disease caused by mutations in the SMN1 (Survival Motor Neuron) gene, which leads to hypotonia and muscle weakness with high mortality related respiratory involvement. Gene therapy (GT) (onasemnogeno aberpavovec) for SMA, through an adeno-associated viral vector 9 (AAV9) was recently approved our country, but its safety efficac...

Herpes zoster or Shingles, an inflammatory viral disease caused by varicella has classical clinical presentation with herpetic morphological pattern exhibited along one or more dermatomes. The self limiting skin disease is accompanied by pain and burning sensations leading to post herpetic neuralgia. The sensory component of the disease is so prominent that the motor involvement is often overlo...

The relationship between exercise and amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by motor neuron loss, rapidly progressive weakness and early death has been controversial. We studied the effect of a high (HEX) and moderate-level exercise (MEX) on body weight, motor performance and motor neuron counts in the ventral horn of spinal cords in a transgenic mouse ...

OBJECTIVE We assessed the orofacial involvement in JDM, and evaluated the possible association of gingival and mandibular mobility alterations with demographic data, periodontal indices, clinical features, muscle enzyme levels, JDM scores and treatment. METHODS Twenty-six JDM patients were studied and compared with 22 healthy controls. Orofacial evaluation included clinical features, dental a...

Six patients severely affected by hereditary motor and sensory neuropathy (HMSN), four type I and two type II, had clinical evidence of diaphragmatic weakness. One presented with cardiorespiratory failure secondary to nocturnal hypoventilation, and three others were unable to lie flat because of dyspnoea. Diaphragmatic paralysis should be considered as a cause of respiratory or cardiac failure ...

RATIONALE Although trigger point injection is known as an easy and low-risk procedure, it is contraindicated to patients with hemorrhagic disorders or who regularly take anticoagulants/antiplatelets. However, taking clopidogrel is not a defined contraindication to this low-risk procedure. PATIENT CONCERNS The chief complaint of a 76-year old woman regularly taking clopidogrel was low back and...