The survival benefits of traditional maximum tolerated dose (MTD) cytotoxic therapy have been modest for the treatment of most types of metastatic malignancy and, moreover, often come with increased acute and chronic toxicity. Recent studies have demonstrated that the frequent administration of comparatively low doses of cytotoxic agents, with no extended breaks [low-dose metronomic (LDM) chemo...

Real-time tumor tracking in external radiotherapy can be achieved by diagnostic (kV) X-ray imaging with a dynamic flat-panel detector (FPD). The purpose of this study was to address image lag in target tracking and its influence on the accuracy of tumor tracking. Fluoroscopic images were obtained using a direct type of dynamic FPD. Image lag properties were measured without test devices accordi...

The basic motif-leucine zipper (bZIP) transcription factor NRL controls the expression of rhodopsin and other phototransduction genes and is a key mediator of photoreceptor differentiation. To delineate the molecular mechanisms underlying transcriptional initiation of rod-specific genes, we characterized different regions of the NRL protein using yeast-based autoactivation assays. We identified...

Long-time integration is an effective method for improving the signal–to–noise ratio (SNR) of echo. However, if target radar cross-section (RCS) fluctuates over long time, traditional coherent and noncoherent methods will produce significant performance losses, making it impossible to achieve a favorable at low SNRs. This study proposes new hybrid based on generalized Radon–Fourier transform (G...

This paper addresses the dynamic path planning for two mobile robots in unknownenvironment with obstacle avoidance and moving target tracking. These robots must form atriangle with moving target. The algorithm is composed of two parts. The first part of thealgorithm used for formation planning of the robots and a moving target. It generates thedesired position for the robots for the next step. ...

The interest in diversity as a security mechanism has recently been revived in various applications, such as Moving Target Defense (MTD), resisting worms in sensor networks, and improving the robustness of network routing. However, most existing efforts on formally modeling diversity have focused on a single system running diverse software replicas or variants. At a higher abstraction level, as...

Abstract: Space-Time Adaptive Processing (STAP) is used in Ground Moving Target Indication (GMTI) to improve the detection of slow or small targets and targets in the presence of jamming. It is used in a number of airborne radar surveillance systems. In order for STAP to be robustly used as part of a practical military sensor it must deliver robust detection performance in all scenarios. In thi...