BACKGROUND Malignant pleural effusion (MPE) and ascites (MA) negatively impact quality of life of palliative patients. Treatment options are limited. This study's purpose is to examine the experience with indwelling tunneled catheters (ITCs) for management of MPE/MA in children with advanced cancer. METHODS Children with MPE/MA who underwent ITC insertion (2007-2012) were retrospectively revi...

Corespondence: Antonia Marazioti, PhD; Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras; Basic Biomedical Sciences Research Building, 2nd floor, Room B40, 1 Asklepiou Str., University Campus (Panepistimioupolis), 26504 Rio, Greece; Phone: +30-2610-969116; Fax: +30-2610-997215; E-mail: [email protected] SUMMARY. Malignan...

IL-17-producing CD4(+) T (Th17) cells have been found to be increased in some human cancers; however, the possible implication of Th17 cells in regulating antitumor responses in malignant pleural effusion (MPE) remains to be elucidated. In the current study, distribution and phenotypic features of Th17 cells in both MPE and peripheral blood from patients with lung cancer were determined by flow...

OBJECTIVE To investigate the diagnostic accuracy of survivin for malignant pleural effusion (MPE). METHODS Pleural effusion samples were collected from 40 MPE patients and 45 non-MPE patients. Pleural levels of survivin were measured by ELISA. Literature search was performed in Pubmed and Embase to identify studies regarding the usefulness of survivin to diagnose MPE. Data were retrieved and ...

Background: Malignant pleural effusion (MPE) comes generally with high mortality and poor prognosis. Recurrence of symptomatic MPE is always accompanied by survival quality. In lung adenocarcinoma, researchers speculate whether patients actionable mutation or without are applicable to different management models for MPE. Under the background probability encouraging therapeutic response in Asian...

Malignant pleural effusion (MPE) is a major problem associated with advanced non-small cell lung cancer for which an optimum treatment strategy has yet to be determined. Notably, vascular endothelial growth factor (VEGF) signaling has been found to influence MPE, and bevacizumab, a VEGF ligand inhibitor, can effectively control MPE. Ramucirumab, a human monoclonal antibody specific for VEGF rec...

Given a belief network with evidence, the task of finding the l most probable ex­ planations (MPE) in the belief network is that of identifying and ordering the l most probable instantiations of the non-evidence nodes of the belief network. Although many approaches have been proposed for solving this problem, most work only for restricted topologies (i.e., singly connected belief net­ works). I...

In order to be successful, enterprises have to adapt quickly to new opportunities and threats. They have to take smart decisions and execute fast. Innovation and agility become main success factors. The Management of Process Excellence (MPE) is a key enabler. It leads to a functioning “real-time enterprise”. MPE links enterprise strategy with people and technology for the highest operational pe...

BACKGROUND The aim of this study was to explore the pharmacokinetic-pharmacodynamic (PK-PD) relationship of metformin on glucose levels after the administration of 250 mg and 1000 mg of metformin in healthy volunteers. METHODS A total of 20 healthy male volunteers were randomized to receive two doses of either a low dose (375 mg followed by 250 mg) or a high dose (1000 mg followed by 1000 mg)...