نتایج جستجو برای: mtd
تعداد نتایج: 1531 فیلتر نتایج به سال:
Comparison of neuropathy-inducing effects of eribulin mesylate, paclitaxel, and ixabepilone in mice.
Chemotherapy-induced neurotoxicity is a significant problem associated with successful treatment of many cancers. Tubulin is a well-established target of antineoplastic therapy; however, tubulin-targeting agents, such as paclitaxel and the newer epothilones, induce significant neurotoxicity. Eribulin mesylate, a novel microtubule-targeting analogue of the marine natural product halichondrin B, ...
PURPOSE To assess the safety and tolerability of the small-molecule allosteric MEK inhibitor refametinib combined with sorafenib, in patients with advanced solid malignancies. EXPERIMENTAL DESIGN This phase I dose-escalation study included an expansion phase at the maximum tolerated dose (MTD). Patients received refametinib/sorafenib twice daily for 28 days, from a dose of refametinib 5 mg pl...
This project evaluates the effectiveness of moving target defense (MTD) techniques using a new game we have designed, called PLADD, inspired by the game FlipIt [28]. PLADD extends FlipIt by incorporating what we believe are key MTD concepts. We have analyzed PLADD and proven the existence of a defender strategy that pushes a rational attacker out of the game, demonstrated how limited the strate...
Background: DE605 is a c-MET inhibitor that can be taken orally. Sorafenib the only treatment has been proven to increase overall survival rates in patients with advanced hepatocellular carcinoma (HCC). However, effectiveness of sorafenib clinical setting limited. By targeting multiple signaling pathways through combination therapy, patient outcomes may improve. This study aimed establish maxim...
This paper proposes a Software-Defined Network (SDN)-based Moving Target Defense (MTD) to protect the network from potential scans in compromised network. As unique feature, contrary traditional MTDs, proposed MTD can work alongside other tools and countermeasures already deployed (e.g., Intrusion Protection Detection Systems) without affecting its behavior. Through extensive evaluation, we sho...
Represented by reactive security defense mechanisms, cyber possesses a static, reactive, and deterministic nature, with overwhelmingly high costs to defend against ever-changing attackers. To change this situation, researchers have proposed moving target (MTD), which introduces the concept of an attack surface define in brand-new manner, aiming provide dynamic, continuous, proactive mechanism. ...
This study aimed to alleviate the theoretical limitations of existing moving target defense (MTD) and decoy concepts improve efficiency defensive deception technology within an organization. We present concept open-source intelligence (OSINT)-based hierarchical social engineering (HS-Decoy) strategy while considering actual fingerprint each In addition, we propose a loosely proactive control-ba...
Chronic bioassays for over 500 chemicals have been conducted under the auspices of the National Cancer Institute and/or the National Toxicology Program (NTP) to screen chemicals for carcinogenicity, providing a wealth of information about bioassays. Typically, chemicals are administered for two years to both sexes in each of one strain of rats and mice generally at the maximum tolerated dose (M...
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