Metallothioneins (MTs) are a family of stress-induced proteins with diverse physiological functions, including protection against metal toxicity and oxidants. They may also contribute to the regulation of cellular proliferation, apoptosis, and malignant progression. We reported previously that the human (h)MT-IIA isoform is induced in carcinoma cells (A431, SiHa, and HT29) exposed to low oxygen...

Recent studies indicate that tissue factor (TF) acts in embryogenesis, metastasis, and angiogenesis. Three independent groups showed that targeted disruption of the murine TF (mTF) gene results in 90% lethality of mTF null embryos at embryonic days 9. 5-10.5. We have demonstrated that expression of wild-type human TF (hTF) from a minigene rescues the embryonic lethality of mTF null embryos. To ...

Atmospheric MTF(Modulation Transfer Function) takes a critical role in restoration of atmospheric blurred RS(Remote Sensing) images. This MTF can be determined by meteorological data. Among the existing deblurring methods of RS images, the meteorological data is not used in estimation of atmospheric MTF. For CBERS-02(China and Brazil Earth Resource Satellite) RS image data, a new deblurring alg...

non-alcoholic fatty liver disease (nafld) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. this study was conceived in a nafld rat model to evaluate the efficacy of both metformin (mtf) and n-acetylcys...

For the image quality analysis of photogrammetrical systems using the Modulation Transfer Function (MTF), the edge gradient analysis (EGA), using a Hanning function, and the grating pattern method are compared. Artificial edge and grating patterns were photographed from an airplane and were analyzed to determine the quality of the photogrammetric system. The pictures were scanned with a microde...

Mammalian metallothionein (MT) genes are transcriptionally activated by the essential metal zinc as well as by environmental stresses, including toxic metal overload and redox fluctuations. In addition to playing a key role in zinc homeostasis, MT proteins can protect against metal- and oxidant-induced cellular damage, and may participate in other fundamental physiologic and pathologic processe...

Autogynephilia is defined as a male's propensity to be sexually aroused by the thought of himself as a female. It is the paraphilia that is theorized to underlie transvestism and some forms of male-to-female (MtF) transsexualism. Autogynephilia encompasses sexual arousal with cross-dressing and cross-gender expression that does not involve women's clothing per se. The concept of autogynephilia ...

Metallothioneins are small, cysteine-rich, metal-binding proteins that play important roles in maintaining intracellular metal homeostasis and in transition metal detoxification. MTF-1 (metal transcription factor-1) plays a central role in regulating the metal-inducible, transcriptional activation of metallothionein. Here we report that the phosphorylation of MTF-1 plays a critical role in the ...

Caenorhabditis elegans mtf-1 encodes matefin, which has a predicted SUN domain, a coiled-coil region, an anti-erbB-2 IgG domain, and two hydrophobic regions. We show that matefin is a nuclear membrane protein that colocalizes in vivo with Ce-lamin, the single nuclear lamin protein in C. elegans, and binds Ce-lamin in vitro but does not require Ce-lamin for its localization. Matefin is detected ...