Introduction: Systematic transrectal ultrasonography (TRUS) biopsy has been the standard diagnostic tool for prostate cancer (PCa) but is subject to limitations, such as a high false-negative rate of detection. Multiparametric magnetic resonance imaging (mpMRI) prior emerging an alternative procedure PCa. The PRECISE study found that MRI followed by targeted was more accurately able identify cl...

PURPOSE To investigate multiparametric functional MRI to characterize acute rejection in a murine allogeneic renal transplant model and evaluate the effect of novel therapeutics. MATERIAL AND METHODS We performed allogeneic and syngeneic orthotopic transplantations (Balb/c to C57Bl/6 and C57Bl/6 to C57Bl/6). Allogeneic Groups (n = 5) were either treated with the anti-CCL2-Spiegelmer (mNOX-E36...

BACKGROUND AND PURPOSE Objective imaging methods to identify optimal candidates for late recanalization therapies are needed. The study goals were (1) to develop magnetic resonance imaging (MRI) and computed tomography (CT) multiparametric, voxel-based predictive models of infarct core and penumbra in acute ischemic stroke patients, and (2) to develop patient-level imaging criteria for favorabl...

Prostate cancer (PCa) is the most common solid-organ malignancy among American men and the second most deadly. Current guidelines recommend a 12-core systematic biopsy following the finding of an elevated serum prostate-specific antigen (PSA). However, this strategy fails to detect an unacceptably high percentage of clinically significant cancers, leading researchers to develop new, innovative ...

The use of multiparametric MRI has been hastened under expanding, novel indications for its in the diagnostic and management pathway men with prostate cancer. This helped drive a large body literature describing evolving role over last decade. Despite this, cancer remains only solid organ malignancy routinely diagnosed random sampling. Herein, we summarize components interpretation, present cri...

High predictive performance and ease of use and interpretability are important requirements for the applicability of a computer-aided diagnosis (CAD) to human reading studies. We propose a CAD system specifically designed to be more comprehensible to the radiologist reviewing screening breast MRI studies. Multiparametric imaging features are combined to produce a CAD system for differentiating ...

• HCC is the most important differential diagnosis for focal liver lesions in the cirrhotic liver • Detection of HCC is crucial to ensure early therapy and proper patient management • Challenging differential diagnoses for HCC are mainly regenerative nodules and pre-neoplastic nodules • MRI provides a multiparametric approach to detect and characterize HCC – including MR signal in T2w images an...