This paper presents a linkage factors synthesis and multi-level optimization technique for bi-stable compliant mechanism. The linkage synthesis problem is modeled as multiple level factors and responses optimization problem with constraints. The bi-stable compliant mechanism is modeled as a crank slider mechanism using pseudo-rigid-body model (PRBM). The model exerts the large deflection of fle...

in this article, multiple-product pvrp with pickup and delivery that is used widely in goods distribution or other service companies, especially by railways, was introduced. a mathematical formulation was provided for this problem. each product had a set of vehicles which could carry the product and pickup and delivery could simultaneously occur. to solve the problem, two meta-heuristic methods...

It has recently been demonstrated that developmental exposure to methylmercury (MeHg) is associated with perseveration on operant tasks. An understanding of the behavioral mechanisms underlying this phenomenon may improve human testing of MeHg exposures and could provide insight into clinical syndromes that include perseveration as a component. One possible mechanism is that MeHg-induced enhanc...

Mikrocytos mackini is an intracellular protistan parasite of oysters whose position in the phylogenetic tree of eukaryotes has been a mystery for many years [1,2]. M. mackini is difficult to isolate, has not been cultured, and has no defining morphological feature. Furthermore, its only phylogenetic marker that has been successfully sequenced to date (the small subunit ribosomal RNA) is highly ...

The exploitation of potential functions in material is crucial in materials research. In this study, we demonstrate a III-VI chalcogenide, polycrystalline γ-In2Se3, which simultaneously possesses the capabilities of thickness-dependent optical gaps and wide-energy-range absorption existed in the polycrystalline layers of γ-In2Se3. Transmission electron microscopy and Raman measurement show a lo...

When optimizing a product or process with multiple responses, a two-stage Pareto front approach is a useful strategy to evaluate and balance trade-offs between different estimated responses to seek optimum input locations for achieving the best outcomes. After objectively eliminating non-contenders in the first stage by looking for a Pareto front of superior solutions, graphical tools can be us...

The murine B29 (Igbeta) promoter is B cell specific and contains essential SP1, ETS, OCT, and Ikaros motifs. Flanking 5' DNA sequences inhibit B29 promoter activity, suggesting this region contains silencer elements. Two adjacent 5' DNA segments repress transcription by the murine B29 promoter in a position- and orientation-independent manner, analogous to known silencers. Both these 5' segment...

4 Functional requirements 10 4.1 Sensitivity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 4.2 Wavelength range . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 4.3 Spectroscopic resolution . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 4.4 Spatial resolution . . . . . . . . . . . . . . . ...