BACKGROUND Multiple complex pathways are operable in the evolution of cutaneous T cell lymphomas (CTCLs). These pathways involve interaction between neoplastic T cells and cells of the immune system (especially dendritic cells and the non-malignant T cells). Granulysin is a proinflammatory antimicrobial peptide which has an immune alarmin function, activating dendritic cells, as well as an acti...

This chapter demonstrates how a neuro-fuzzy approach could produce outputs of a further-modified multi-criteria decision-making (MCDM) quality function deployment (QFD) model within the required error rate. The improved fuzzified MCDM model uses the modified S-curve membership function (MF) as stated in an earlier chapter. The smooth and flexible logistic membership function (MF) finds out fuzz...

The cerebellum receives extensive disynaptic input from the neocortex via the basal pontine nuclei, the neurons of which send mossy fiber (MF) axons to the granule cell layer of the contralateral cerebellar hemisphere. Although this cortico-cerebellar circuit has been implicated in tasks such as sensory discrimination and motor learning, little is known about the potential role of MF morphologi...

background: onchocerciasis is endemic in the imo river basin, nigeria. this study was aimed at assess­ing the prevalence and intensity of microfilaria of onchocerca volvulus in the area. methods: a cross-sectional study was carried out in the okigwe local government area, imo state, nige­ria. two skin snips (one from the waist and another from the shoulder) were taken from 1024 individu­als exa...

The total variation (TV) denoising method is a PDE-based technique that preserves the edges well but has undesirable staircase effect in some cases, namely, the translation of smooth regions (ramps) into piecewise constant regions (stairs). This paper introduces a novel mesh-free approach using TV (ROFmodel) regularization and radial basis function (RBF) for the numerical approximation of TV-ba...

j=1 yj φ(‖x − xj‖2), x ∈ R , where φ: [0,∞) → R is some given function, (yj) n 1 are real coefficients, and the centres (xj) n 1 are points in R. For a wide class of functions φ, it is known that the interpolation matrix A = (φ(‖xj − xk‖2)) n j,k=1 is invertible. Further, several recent papers have provided upper bounds on ‖A‖2, where the points (xj) n 1 satisfy the condition ‖xj − xk‖2 ≥ δ, j ...

BACKGROUND The loss of skeletal muscle mass (MM) or muscle function (MF) alone increases the risk for losing physical independence in older adults. We aimed to examine the independent and synergic associations of low MM and low MF, both criteria of sarcopenia, with the risk for losing projected physical independence in later life (+90 years old). METHODS Cross-sectional analyses were conducte...

EZH2 is a component of polycomb repressive complex 2 (PRC2) and functions as an H3K27 methyltransferase. Loss-of-function mutations in EZH2 are associated with poorer outcomes in patients with myeloproliferative neoplasms (MPNs), particularly those with primary myelofibrosis (MF [PMF]). To determine how EZH2 insufficiency is involved in the pathogenesis of PMF, we generated mice compound for an...

Evolution of the mass function (MF) and radial distribution (RD) of the Galactic globular cluster (GC) system is calculated using an advanced and realistic Fokker-Planck (FP) model that considers dynamical friction, disc/bulge shocks, and eccentric cluster orbits. We perform hundreds of FP calculations with different initial cluster conditions, and then search a wide parameter space for the bes...

Whether multifrequency bioelectrical impedance analysis (MF-BIA), a relatively new method for measuring body composition, is also applicable for accurate body composition measurements in renal transplant (RTx) patients is not known. Therefore, the use of MF-BIA is validated in 77 RTx patients with a stable renal function at least 2 yr posttransplantation. MF-BIA is compared to isotope dilution ...