نتایج جستجو برای: mune
تعداد نتایج: 196 فیلتر نتایج به سال:
Inhibition of tumor growth in a murine transplantable model of bladder cancer was attempted through manipulation of im mune response mechanisms by treatment of experimental an imals with indomethacm, a prostaglandin synthetase inhibitor, and/or polyinosinic:polycytidylic acid [poly(l:Q], an inducer of Interferon. Tumor-bearing animals and age-matched controls were inoculated i.p. with either ph...
Recent studies have demonstrated that advanced neoplastic disease is often associated with a general impairment of im mune function (15, 17, 29). High levels of serum immunoreg ulatory factors which nonspecifically inhibit in vitro and in viva lymphocyte function (13, 17, 21 , 25, 28, 39, 40, 45) are thought to account for the depressed immune status of anergic cancer patients (13, 33). Further...
Downlo cer vaccine feasibility would benefit from reducing the number and duration of vaccinations without ishing efficacy. However, the duration of in vivo studies and the huge number of possible variations cination protocols have discouraged their optimization. In this study, we employed an established model of preventive vaccination using HER-2/neu transgenic mice (BALB-neuT) to validate o–d...
The experiments reported in this paper were designed to investigate the in vitro interaction of immune sera with different antibody titers as determined by indirect mem brane immunofluorescence (MF) with normal or immune lymphoid cells in mediating target cell destruction. Target cells in these experiments were two Moloney sarcoma virus (MSV)-induced tumor cell lines derived from BALB/c and C57...
There are currently no available options to promote nerve regeneration through chronically denervated distal nerve stumps. Here we used a rat model of delayed nerve repair asking of prior insertion of side-to-side cross-bridges between a donor tibial (TIB) nerve and a recipient denervated common peroneal (CP) nerve stump ameliorates poor nerve regeneration. First, numbers of retrogradely-labell...
UNLABELLED Preliminary in vitro and in vivo studies with valproic acid (VPA) in cell lines and patients with spinal muscular atrophy (SMA) demonstrate increased expression of SMN, supporting the possibility of therapeutic benefit. We performed an open label trial of VPA in 42 subjects with SMA to assess safety and explore potential outcome measures to help guide design of future controlled clin...
able phospholipid membranes. Such vesicular structures with a purely lipid outer surface might be expected to have a distribution pattern different from that of the entrapped species. Several reports have now indicated that the distribution of proteins and drugs in VIVOis indeed altered when they are entrapped in phospholipid liposomes (8, 11, 16, 30). Studies on their effectiveness have indica...
Amyotrophic lateral sclerosis (ALS) belongs to a group of disorders known as motor neuron diseases. Despite being one of the most devastating diseases known, there is little evidence for diagnosing and managing patients with ALS. Clinical neurophysiologic tests are essential, when no biological marker exists to aid early diagnosis, not only in relation to diagnosis, but also in the development ...
mune response. It has been demonstrated to correlate with stage of disease (1, 6, 16, 31) and prognosis (2, 3, 14, 20) in many types of cancer. By various mechanisms, including surgery (17, 18), radiotherapy (8, 23), chemotherapy (23), and immunotherapy (11, 15, 32, 33), the human immune response can be altered.These changes can be docu mented with DTH skin tests, and thus this test of immuno l...
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