Sporadic mitral valve prolapse (MVP) is one of the most common acquired cardiac valvular abnormalities in industrialized nations. It is a leading cause of isolated mitral regurgitation and is associated with various complications such as infectious endocarditis, heart failure, atrial fibrillation, stroke and death. Myxomatous degeneration involves the spongiosa of the mitral valve leaflets and ...

Although mitral valve prolapse (MVP) is a benign entity overall, there small subset of patients with MVP, particularly bileaflet who may experience life-threatening ventricular arrhythmias (VAs) secondary to arrhythmogenic MVP syndrome. Studies characterizing this group have been limited by sample sizes and single center design. To assemble worldwide case series examining the clinical phenotype...

Familial dysautonomia is a rare syndrome of childhood affecting the nervous system. As the name suggests, dysfunction of the autonomic system is a prominent feature. It was first recognized as a separate entity by Riley, Day, Greeley and Langford (1949), the first large series being described by Riley (1952). So far, about 70 patients have been recorded. Though the fully developed syndrome is u...

Dysautonomia refers to a disease where the autonomic nervous system is dysfunctional. This may be a central control mechanism, as in genetically determined familial dysautonomia (Riley-Day Syndrome), or peripherally in the distribution of the sympathetic and parasympathetic systems. There are multiple reports of a number of different diseases associated with dysautonomia. The etiology of this a...

The interstitial fluid pressure (IFP) has been found to be as high as 20 to 50 mm Hg in both experimental and human solid tumors. While the IFP is an important determinant of the delivery of therapeutic agents to neoplastic cells in vivo, the mechanisms responsible for interstitial hypertension are not completely understood. The high vascular permeability of tumor blood vessels and the absence ...

BACKGROUND Mitral valve prolapse (MVP) is accompanied by mental disorders including anxiety, which has similar presentations as MVP. It is hypothesised that treatment of anxiety might reduce the symptoms of MVP. OBJECTIVE The aim of this study was to assess the clinical and echocardiographic effects of fluoxetine administration in patients with MVP and anxiety. METHODS This randomized clini...

BACKGROUND Phase III studies suggest that non-small-cell lung cancer (NSCLC) patients treated with cisplatin-docetaxel may have higher response rates and better survival compared with other platinum-based regimens. We report the final results of a randomised phase III study of docetaxel and carboplatin versus MIC or MVP in patients with advanced NSCLC. PATIENTS AND METHODS Patients with biops...

OBJECTIVE Biogenic amine brain levels and their cerebral metabolism are frequently studied by quantitation of biogenic amine metabolites in cerebrospinal fluid (CSF) compared to age-matched controls. There is a paucity of studies in adolescents and young adults investigating the potential role of disordered cerebral biogenic amine metabolism in young patients who have dysautonomia based on abno...

The Multimission VICAR Planner (MVP) system is an AI planning system which constructs executable image processing programs to support Operational Science Analysis (OSA) requests made to the Jet Propulsion Laboratory (JPL) Multimission Image Processing Subsystem (MIPS). MVP accepts as input: image files and a high-level specification of desired corrections, enhancements, output properties (such ...

The clinical and laboratory features of 24 patients with proven mitral valve prolapse (MVP) and brain dysfunction are reported. The age range of affected patients was between 20 and 63 years (average of 43) and 70 percent were women. MVP was documented prior to the brain illness in only 4 patients. The majority of patients experienced bland cerebral infarction. Disorders also included transient...