This paper concerns (but does not succeed in performing) the diffeomorphism classification of closed, oriented, differential, simply-connected 4-manifolds. It arises out of the observation (due to Pontrjagin and Milnor [2]) that if two such manifolds Mx and M2 have isomorphic quadratic forms of intersection numbers on #2(Jft-), then there is a map / : M1-^-Mi which is a homotopy equivalence and...

Modeling both genetic and cultural transmission in parent-offspring data in the presence of phenotypic assortment requires the imposition of nonlinear constraints. This article reports a simulation study that determined how well the structural equation modeling software package Mx and the Bayesian-oriented BUGS software package can handle such nonlinear constraints under various conditions. Res...

It is suggested that the measurements of hadronic invariant mass (mX) distributons in the inclusive B → Xc(u)lν decays can be useful in extracting the CKM matrix element |Vub|. We investigated hadronic invariant mass distributions within the various theoretical models of HQET, FAC and chiral lagrangian as well as ACCMM model. It is also emphasized that the mX distribution even at the region mX ...

In vertebrates, host defense against pathogens is mediated by two general systems: innate and acquired immunity. Innate immunity constitutes the first line of defense, providing a rapid response by the expression of germ-line encoded proteins that preexist or are induced within hours of infection. Adaptive immunity is a slower, yet highly specific response mediated by B and T lymphocytes that c...

UNLABELLED Analyzing and visualizing multiple sequence alignments is a common task in many areas of molecular biology and bioinformatics. Many tools exist for this purpose, but are not easily customizable for specific in-house uses. Here we report the development of an editor, CINEMA-MX, that addresses these issues. CINEMA-MX is highly modular and configurable, and we present examples to illust...

Pooled testing (also known as group testing), where diagnostic tests are performed on pooled samples, has broad applications in the surveillance of diseases animals and humans. An increasingly common use case is molecular xenomonitoring (MX), vector-borne conducted by capturing large numbers vectors (e.g. mosquitoes). The R package PoolTestR was developed to meet needs complex surveys but can b...

For a connected graph G of order p ≥ 2 and a vertex x of G, a set S ⊆ V (G) is an x-monophonic set of G if each vertex v ∈ V (G) lies on an x− y monophonic path for some element y in S. The minimum cardinality of an x-monophonic set of G is defined as the x-monophonic number of G, denoted by mx(G). An x-monophonic set of cardinality mx(G) is called a mx-set of G. We determine bounds for it and ...

INTRODUCTION Nipple-areola sparing mastectomy (NSM) is increasingly used in patients with non-locally advanced breast carcinoma. Literature data on the preoperative assessment of the nipple-areola complex (NAC) are inconsistent. PATIENTS AND METHODS Out of 1359 patients submitted to total mastectomy between 2001 and 2010, we selected 61 patients whose pre-operative mammogram (MX) was availabl...

Although c-Abl has increasingly emerged as a key player in the DNA damage response, its role in this context is far from clear. We studied the effect of inhibition of c-Abl kinase activity by imatinib with chemotherapy drugs and found a striking difference in cell survival after combined mitoxantrone (MX) and imatinib treatment compared to a panel of other chemotherapy drugs. The combinatory tr...