Abstract Despite the remarkable outcome of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC), a large number patients remain unresponsive to this therapy. A key factor unresponsiveness ICIs is intrinsic therapeutic resistance where monocytic myeloid-derived suppressor cells (M-MDSCs) contribute significantly via suppressing CD8 +T mediated anti-tumor response. Our result...

Advances in immunotherapy have underscored the importance of antitumor immune responses controlling cancer. However, tumor microenvironment (TME) imposes several obstacles to proper function cells, including a metabolically challenging and immunosuppressive microenvironment. The increased metabolic activity cells can lead depletion key nutrients required by accumulation byproducts that hamper i...