N manifestations of acute leukemia are due to direct involvement by meningeal infiltration and myeloid sarcoma; and indirect involvement by immunosuppression and treatment related side effects. It is rare for myeloid sarcoma to present without bone marrow involvement (isolated myeloid sarcoma or primary granulocytic sarcoma).1 It is even rarer for an isolated myeloid sarcoma to present in the e...

A series of 7 patients with granulocytic sarcoma is presented to illustrate its varied clinical picture. In particular, this condition may present with features which suggest a non-Hodgkin lymphoma. The diagnosis will only be made if a high index of suspicion is maintained and special histopathological methods are used. Granulocytic sarcoma should be treated like an acute myeloid leukaemia.

Objective: Acute myeloid leukemia (AML) is characterized by leukemic blasts that are not limited to the bone marrow or peripheral blood, may be presented with granulocytic sarcoma, and cells outside of blood called extramedullary involvement (EMI). Skin, bone, lymph nodes most prevalent locations illness. Granulocytic sarcoma (GS) should considered in differential diagnosis nodules, pustules, p...

Granulocytic sarcoma is a rare variant of a myeloid malignancy, which shows an extra-medullary tumour mass which is composed of myeloblasts and myeloid precursors with varying degrees of differentiation. It occurs most commonly in bone, periosteum, soft tissue, lymph nodes, and skin; although it can occur anywhere throughout the body. Here, we are reporting two cases of orbital granulocytic sar...

According to previous reports, cutaneous myeloid sar-coma often manifests as a red nodule on the skin. We report here a patient with cutaneous myeloid sarcoma presenting with a unique skin lesion. A 71-year-old man presented with pigmented macules of one month duration. Physical examination showed multiple grey pigmented macules, 10–30 mm in diameter , on the face and trunk (Fig. 1a). His white...

Myeloid sarcoma is a tumor mass consisting of myeloid blasts, with or without maturation, occurring in an anatomical site other than bone marrow. More 2000 case reports so far, only few comprehensive studies have been done, which reflects the rarity and difficulties treatment this neoplasm. : A 17-year-old female presented complaints neck swelling since 2 months, breathlessness 5 days. PET CT- ...

Myeloid sarcoma results from the extramedullary homing and proliferation of immature myeloid precursors. We present the timeline, events and diagnostic pitfalls related to a 66 year-old male patient's case, admitted to the Hematology Clinic for pancytopenia, fever, weight loss and fatigue. The severe cytopenia and the few blasts observed in his blood smear indicated a bone marrow biopsy. The bo...

Background: Myeloid sarcoma (MS) or granulocytic sarcoma is a rare tumor consisting of myeloid blasts with or without maturation occurring at anatomic sites other than the bone marrow. MS can involve any organ system but shows a predilection for skin, bone, and soft tissues of head and neck region. Case report: We report four cases of MS occurring at unusual sites, out of which three were de no...

Granulocytic sarcoma (GS) is an extremely rare condition involving infiltration of myeloblasts or immature myeloid cells in an extramedullary site. It is also known as chloroma, myeloid sarcoma or extramedullary myeloid tumor. It usually occurs concomitantly with acute myelogenous leukemia or with the onset of blastic phase of chronic myelogenous leukemia. On rare occasions, it evolves even bef...

Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. T...