نتایج جستجو برای: myocyte enhancer factor 2
تعداد نتایج: 3167311 فیلتر نتایج به سال:
In the mammalian nervous system, neuronal activity regulates the strength and number of synapses formed. The genetic program that coordinates this process is poorly understood. We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocampal neurons formed synapses. In response to inc...
The members of myocyte Enhancer Factor 2 (MEF2) protein family was previously believed to function in the development of heart and muscle. Recent reports indicate that they are also closely associated with development and progression of many human diseases. Although their role in cancer biology is well established, the molecular mechanisms underlying their action is yet largely unknown. MEF2 fa...
Background-—Class IIa histone deacetylase (HDAC) isoforms such as HDAC5 are critical signal-responsive repressors of maladaptive cardiomyocyte hypertrophy, through nuclear interactions with transcription factors including myocyte enhancer factor-2. b-Adrenoceptor (b-AR) stimulation, a signal of fundamental importance in regulating cardiac function, has been proposed to induce both phosphorylati...
Protein Kinase A Represses Skeletal Myogenesis by Targeting Myocyte 3 Enhancer Factor 2D 4 5 Min Du, Robert L. S. Perry, Nathaniel B. Nowacki, Joseph W. Gordon, Jahan 6 Salma, Jianzhong Zhao, Arif Aziz, Joseph Chan, K. W. Michael Siu, John C. 7 McDermott 8 1 Department of Biology, York University, Toronto M3J 1P3, Ontario, Canada; 2 Centre 9 for Research in Mass Spectrometry, York University, T...
RATIONALE The peptide ligand apelin and its receptor APJ constitute a signaling pathway with numerous effects on the cardiovascular system, including cardiovascular development in model organisms such as xenopus and zebrafish. OBJECTIVE This study aimed to characterize the embryonic lethal phenotype of the Apj-/- mice and to define the involved downstream signaling targets. METHODS AND RESU...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید