About 50% of the fatty acids in retinal rod outer segments is docosahexaenoic acid [22:6(n-3)], a member of the linolenic acid [18:3(n-3)] family of essential fatty acids. Dietary deprivation of n-3 fatty acids leads to only modest changes in 22:6(n-3) levels in the retina. We investigated the mechanism(s) by which the retina conserves 22:6(n-3) during n-3 fatty acid deficiency. Weanling rats w...

For n ≤ 27 we present exact values for the maximum number h(n) of halving lines and eh(n) of halving pseudolines, determined by n points in the plane. For this range of values of n we also present exact values of the rectilinear cr(n) and the pseudolinear e cr(n) crossing number of the complete graph Kn. eh(n) and e cr(n) are new for n ∈ {14, 16, 18, 20, 22, 23, 24, 25, 26, 27}, h(n) is new for...

The synthesis of 4,7,10,13,16,19-docosahexaenoic acid (22:6(n-3)) requires that when 6,9,12,15,18,21-tetracosahexaenoic acid (24:6(n-3)) is produced in the endoplasmic reticulum, it preferentially moves to peroxisomes for one cycle of beta-oxidation rather than serving as a substrate for membrane lipid synthesis. Both 24:6(n-3) and its precursor, 9,12,15,18,21-tetracosapentaenoic acid (24:5(n-3...

For n ≤ 27 we present exact values for the maximum number h(n) of halving lines and eh(n) of halving pseudolines, determined by n points in the plane. For this range of values of n we also present exact values of the rectilinear cr(n) and the pseudolinear e cr(n) crossing number of the complete graph Kn. eh(n) and e cr(n) are new for n ∈ {14, 16, 18, 20, 22, 23, 24, 25, 26, 27}, h(n) is new for...

N-3 trans geometrical isomers of 20:5 n-3 and 22:6 n-3 were isolated from rats fed heated linseed oil. The ability of these acids to inhibit 20:4 n-6 metabolism by human platelets was examined. The concentrations required to inhibit 50% of platelet aggregation (IC50) induced by 2.5 microM 20:4 n-6 were higher for the 20:5 delta 17t isomer compared to all cis 20:5 n-3; means 29.2 and 7.6 microM,...