BACKGROUND Dilated cardiomyopathy (DCM) involves significant remodeling of the left ventricular-mitral valve (MV) complex, but little is known regarding the remodeling of the mitral leaflets. The aim of this study was to assess changes in matrix composition and turnover in MV leaflets with DCM. METHODS AND RESULTS Radiopaque markers were implanted in 24 sheep to delineate the MV; 10 sheep und...

OBJECTIVE To examine in a community-based cohort: (1) the prevalence of chronic tic disorder (CTD) in children with attention-deficit/hyperactivity disorder (ADHD) compared with non-ADHD controls at ages 7 and 10; and (2) the additional psychiatric and functional burden of CTD in children with ADHD. METHODS Children aged 6-8 years with ADHD (n=179) and controls (n=212) were recruited through ...

BACKGROUND The inability to inhibit unwanted behaviors and impulses produces functional debility in a broad range of neuropsychiatric disorders. A potentially important model of impulse control is volitional tic suppression in Tourette syndrome. METHODS Tic suppression was studied in 22 adult subjects with Tourette syndrome by using functional magnetic resonance imaging. Images acquired durin...

Core-shell TiO(2)/C and TiC/C nanofibers are fabricated in situ on Ti and Al ion-implanted Ti substrates by a thermochemical reaction in acetone and the growth mechanism is described. Implantation of Al into Ti leads to in situ growth of TiC/C in lieu of TiO(2)/C nanofibers. This is because Al has a higher affinity to oxygen than Ti and Ti reacts preferentially with C to form TiC. The Ti foil s...

OBJECTIVE Despite evidence of elevated risk factors for suicidal thoughts and behavior in youth with Tourette syndrome and chronic tic disorders (CTD), few studies have actually examined that relationship. This study documented the frequency and clinical correlates of suicidal thoughts and behaviors in a sample of children and adolescents with CTD (N = 196, range 6-18 years old). The content is...

Abstract NiMo-5%TiC, NiMo-15%TiC, and NiMo-25%TiC coatings were prepared on GCr15 steel by laser cladding (LC). The microstructure the phases of obtained analyzed using ultra-depth-of-field microscopy (UDFM) X-ray diffraction (XRD), respectively. A ball-on-disk wear test was used to analyze friction-wear performance substrate NiMo-TiC under grease-lubrication condition. results show that grain ...

AIM We aimed to investigate the contribution of the touch imprint cytology (TIC) of core needle biopsies (CNBs) to the diagnosis in spinal lesions. MATERIAL AND METHODS Sixty cases with spinal CNB and TIC were included in the study. Hematoxylin and Eosin (H&E) and May-Grunwald- Giemsa (MGG) stained TIC slides and CNB of each case were blindly reevaluated by two pathologists. TIC and CNB findi...

OBJECTIVE The aim of this study was to conduct a pilot study testing whether single-dose, immediate-release dexmethylphenidate (dMPH) can facilitate tic suppression in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and Tourette's disorder (TD) or chronic tic disorders. The primary hypothesis is that dMPH will improve behaviorally reinforced tic suppression in a st...