Cooxidation of xenobiotics may occur during prostaglandin biosynthesis. The ability of prostaglandin endoperoxide synthetase to cooxidize several aromatic amines and other chemicals to mutagenic products was tested with the standard Salmonella tester strains. The microsomal fraction of ram seminal vesicles, a rich source of prostaglandin endoperoxide synthetase, in the presence of the prostagla...
