water soluble chitosan oligosaccharide (cho) was hydrophobically modified with camptothecin (cpt) in different molar ratios of cpt, and characterized by ft-ir and 1 h-nmr spectroscopy. nanomicelles prepared by these copolymers were analyzed for size, zeta, and length of time they remain stable. the critical micelle concentration (cmc) and dissociation of micelles at physiological ph and acidic ...

Biocatalysis is increasingly being explored for the sustainable development of green industry. Though enzymes show great industrial potential with their high efficiency, specificity, and selectivity, they suffer from poor usability stability under abiological conditions. To solve these problems, researchers have fabricated nano- micro-sized biocatalytic reactors based on self-assembly various p...

Drug delivered can have significant effect on its efficacy. Some drugs have an optimum concentration range with in which maximum benefit is derived and concentrations above (or) below the range can be toxic or produce no therapeutic effect. Various drug delivery and drug targeting systems are currently under development. The main goal for developing such delivery systems is to minimize drug deg...

The surface composition and functionality of biomaterials and scaffolds are the most important factors for their applications in biomedical fields and tissue regeneration. Bulk and surface properties of biomaterials influence vital cell activities such as cell adhesion, proliferation, extracellular matrix secretion, and differentiation. Nano-/microstructural control is found to be another key f...

pluronic/bile salt/phospholipid mixed micelles (pluronic/bs/ps-mm) drug carrier system for solubilization hydrophobic drugs was developed. a typical hydrophobic compound, pyrene, was selected as a representative hydrophobic compound to model the hydrophobic drugs. five pluronics, f68, f88, f98, f108, and f127 with different ppo chain length were studied. cmc data and solubilization capacities w...

Prostate tumor cell targeted peptide fragment conjugated to the nano drug delivery system is a promising strategy for prostate cancer therapy. In this work, an amphiphilic copolymer Chol-PEG-DUP1 (PEG-cholesterol conjugated with DUP1 peptide) has been synthesized and characterized by proton nuclear magnetic resonance spectrum ((1)H NMR). The paclitaxel (PTX) was encapsulated into the Chol-PEG-D...

In this paper, we have systematically investigated the aggregation behavior, confined crystallization and controlled growth of a novel polyolefin analogue-containing block copolymers (BCPs), i.e., polymethylene-b-poly(acrylic acid) diblock copolymers (PM-b-PAA). On cooling from a homogenous DMF solution at 80 °C, PM-b-PAA was found to crystallize and aggregate with well-defined disk-like micell...

The potency of nanoparticles, loaded with drugs, genes, and/or diagnostics, is frequently depending upon their morphology adopted in a biological relevant environment. Freeze-fracture electron microscopy is a powerful techniques to monitor the self-assembling of lipid-, polymer-, as well as protein/peptide-based drug and gene carries on a nano-size resolution scale. Freeze-fracture electron mic...