The cover presents the active pharmaceutical ingredient paclitaxel (PTX) loaded in nanorocket propelling to malignant proliferative cells. It illustrates a “three-vector” design for nanomedicine development, drug payload on nanocarrier, accompanied by functional molecules implement targeted delivery and stimulus-responsive release. This is reported Xin-Ming Xu, Hui Tao Zhang, co-workers article...

Cathepsin B (CtsB) is a lysosomal cysteine proteinase that is specifically translocated to the extracellular milieu during cancer progression. The development of a lipidated CtsB inhibitor incorporated into the envelope of a liposomal nanocarrier (LNC-NS-629) is described. Ex vivo and in vivo studies confirmed selective targeting and internalization of LNC-NS-629 by tumor and stromal cells, thu...

A new concept for the development of semiconductor field-effect biosensors by modification of a gate surface with tobacco mosaic virus (TMV) nanotubes, serving as enzyme nanocarrier, is presented. TMV nanotubes enable an immobilization of a high amount of enzymes without substantial loss of their activity, resulting in an enhanced biosensor performance. This approach has been experimentally dem...

Bioinspired cell deformation aids in the design of smart functional molecular self-assemblies. We report on a system of bacteria-like vesicles which release entrapped drug upon developing hairs triggered by UV irradiation, just like cilia stretching from the surface of bacteria. The formation of cilia leads to a less intact membrane, which allows release of entrapped drug. This bioinspired desi...

Cancer Therapy In article number 2202694, Dong-Hyun Kim and co-workers develop reactive oxygen species (ROS)–responsive biodegradable metallic nanoparticles that can be used for various biomedical applications. Given the challenges of non-biodegradability potent inorganic nanoparticles, introduction a ROS-responsive cleavable hierarchical supra-nanostructure provides an exciting opportunity ROS...