A METHOD IS DESCRIBED FOR ANALYZING THE ASSOCIATION OF THE OPIATE NARCOTIC LEVORPHANOL WITH BRAIN TISSUE INTO THREE COMPONENTS: nonsaturable, saturable nonspecific, and saturable stereospecific. The method may be of general applicability for the study of the interaction of drugs with body tissues. In mouse brain the stereospecific binding of levorphanol represents only 2% of the total associati...

introduction in spite of the increasing trend in opioid abusers worldwide, the prevalence of narcotic bowel syndrome (nbs) is undetermined. we aimed to estimate the prevalence of nbs and other opioid bowel dysfunction (obd) in opioid abusers in kerman, southeast iran. according to the best of our knowledge, this is the first study to assess the prevalence of nbs in opioid abusers. method by ref...

Introduction. Destruction is one of the stages circulation medicines. Special importance attached to this stage in relation drugs related narcotic and psychotropic substances. The activities pharmacy medical organizations turnover these funds are strictly regulated. Aim. purpose study was procedure for destruction substances included Lists II III List, as a medicines, identify trends appointmen...

Alcohol and benzodiazepines may increase sleep-disordered breathing by decreasing activity of pharyngeal dilating muscles, favoring the development of obstructive apneas and hypopneas. Narcotics cause greater depression of wakeful respiration than the previously mentioned drugs; however, the influence of narcotics on the upper airway and breathing during sleep has not been studied. We, therefor...

IN the past decade narcotic analgesics have been widely used to supplement thiopentone-nitrous oxide-oxygen anaesthesia. Pethidine (Neff, Mayer and Perales, 1947) and alphaprodine (Siker, Foldes, Pahk and Swerdlow, 1954) have been most frequently employed, but many other narcotics, e.g. levorphanol (Brotman, Cullen and Wilkins, 1950) and anileridine (Riffin et al., 1958) have also been used. In...

Abstract Background and objective: NAS is a combination of signs and symptoms that due to physical and mental dependency, develops in neonates born from drug addicted mothers. The onset of NAS varies in accordance with the type, amount, frequency and duration of substance used. Because of diverse and unclear pattern of substance abuse in Iranian addicted pregnant mothers in comparison with west...

Narcotic antitussives such as codeine reveal the antitussive effect primarily via the mu-opioid receptor in the central nervous system (CNS). The kappa-opioid receptor also seems to contribute partly to the production of the antitussive effect of the drugs. There is controversy as to whether delta-receptors are involved in promoting an antitussive effect. Peripheral opioid receptors seem to hav...

At present probably the most popular and effective method to alleviate the withdrawal symptoms in narcotic addicts is the substitution of the stronger narcotics by methadone which because of its milder addictiveness can be more easily and rapidly withdrawn (Weiland and Chambers, 1970). However, methadone itself is an addictive drug, its abuse liability being enhanced by the fact that it can als...