Antigen Ki-67 is a non-histone nuclear protein, closely connected with cell proliferation. Determining Ki-67 allows for a quick and reliable evaluation of the growth fraction of the studied cell population. It serves as a marker of proliferative activity in neoplasms and other diseases with excessive cell proliferation such as psoriasis. Evaluation of Ki-67 expression in epidermal cells was per...

Vitiligo is an acquired pigmentary disorder characterized by depigmentation of skin and hair. Melanocyte migration is an important event in re-pigmentation of vitiligo. We have demonstrated that narrow-band ultraviolet B (UVB) irradiation stimulated cultured keratinocytes to release a significant amount of basic fibroblast growth factor (bFGF). Furthermore, narrow-band UVB enhanced migration of...

Narrow-band (312 nm) ultraviolet B light (UVB) is a new form of therapy for psoriasis, but its mechanism of action is unknown. In a bilateral comparison clinical study, daily exposure of psoriatic plaques to broad-band UVB (290-320 nm) or 312-nm UVB depleted T cells from the epidermis and dermis of psoriatic lesions. However, 312-nm UVB was significantly more depleting in both tissue compartmen...

BACKGROUND Several new treatments appear to have higher success rates than previous therapies for the treatment of vitiligo, and targeted phototherapy is an alternative that may prove to be time-efficient and an effective therapeutic option for the management of this condition. OBJECTIVE The aim of this study was to evaluate the efficacy of targeted broadband UVB phototherapy for the treatmen...

BACKGROUND Patients receiving phototherapy for various dermatoses are at increased risk of eye damage due to ultraviolet (UV) rays. They are prescribed UV protective sunglasses by dermatologists but their exact protecting effects are not known. AIM To study the ultraviolet protective properties of branded and unbranded UV protective sunglasses available in the Indian market, in UV phototherap...

Ultraviolet B (UVB) phototherapy is a common treatment modality in patients with atopic dermatitis, but whether it increases the risk of skin cancer has not been studied. To address issue, we conducted nationwide population-based cohort study using data from National Health Insurance Taiwan, Taiwan Cancer Registry, and national death registry Taiwan. Adult who received their first UVB during 20...

Background: Psoriasis is a chronic, recurrent, inflammatory skin disease that alters the quality of life. Systemic therapy and biologic agents are prescribed for severe widespread psoriasis, but these drugs may have systemic side effects immune suppression. Narrowband Ultraviolet B (NB-UVB) phototherapy remains one most effective safe treatments psoriasis.Methods: This study was an observationa...

Abstract Background Psoriasis is a chronic and non-transient disease with increased epidermal proliferation in the skin. Dysregulation of immune system an important factor this pathology. Inflammation markers, pro-inflammatory cytokines, cells are reported to be changed psoriasis. Study design In current cohort study, possible changes interleukin-6 (IL-6), neopterin levels, kynurenine (Kyn) pat...

Vitiligo is a common, acquired pigmentary disorder of unknown pathogenesis that presents a therapeutic challenge to many dermatologists (Figure 1). Although surgery in the form of grafting or transplantation is generally the most definitive treatment option, these procedures are limited by concerns of post-procedure cosmesis. Photochemotherapy using psoralen and ultraviolet A (PUVA) therapy, to...

Keratosis lichenoides chronica (KLC) is a rare keratotic disorder of unknown origin. Effective treatment has not been established yet. Here, we present adult-onset KLC, which was treated by narrow-band ultraviolet B (NB-UVB) monotherapy. Although NB-UVB was reported to be effective for pediatric-onset KLC, it has not been clear if this regimen is also useful for adult-onset type because pediatr...