Substantial evidence has shown that most exogenous substances are metabolized by multiple cytochrome P450 (P450) enzymes instead of by merely one P450 isoform. Thus, multi-P450 inhibition leads to greater drug-drug interaction risk than specific P450 inhibition. Herein, we innovatively established an artificial neural network cascade (NNC) model composed of 23 cascaded networks in a ladder-like...

Iron is a widely used metal due to its low cost and availability, but it susceptible corrosion in many circumstances. This can result economic environmental losses, negatively affect the physical chemical properties of metal. chapter provides background on iron archaeology introduces various inhibitors for protection. It starts with general overview metallurgy iron, followed by an in-depth expl...